Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030605887> ?p ?o ?g. }
- W2030605887 endingPage "2852" @default.
- W2030605887 startingPage "2837" @default.
- W2030605887 abstract "Ascending urinary tract infection (UTI) and pyelonephritis caused by uropathogenic Escherichia coli (UPEC) are very common infections that can cause severe kidney damage. Collecting duct cells, the site of hormonally regulated ion transport and water absorption controlled by vasopressin, are the preferential intrarenal site of bacterial adhesion and initiation of inflammatory response. We investigated the effect of the potent V2 receptor (V2R) agonist deamino-8-D-arginine vasopressin (dDAVP) on the activation of the innate immune response using established and primary cultured collecting duct cells and an experimental model of ascending UTI. dDAVP inhibited Toll-like receptor 4-mediated nuclear factor kappaB activation and chemokine secretion in a V2R-specific manner. The dDAVP-mediated suppression involved activation of protein phosphatase 2A and required an intact cystic fibrosis transmembrane conductance regulator Cl- channel. In vivo infusion of dDAVP induced a marked fall in proinflammatory mediators and neutrophil recruitment, and a dramatic rise in the renal bacterial burden in mice inoculated with UPECs. Conversely, administration of the V2R antagonist SR121463B to UPEC-infected mice stimulated both the local innate response and the antibacterial host defense. These findings evidenced a novel hormonal regulation of innate immune cellular activation and demonstrate that dDAVP is a potent modulator of microbial-induced inflammation in the kidney." @default.
- W2030605887 created "2016-06-24" @default.
- W2030605887 creator A5001718959 @default.
- W2030605887 creator A5007793971 @default.
- W2030605887 creator A5010002554 @default.
- W2030605887 creator A5022571530 @default.
- W2030605887 creator A5023281192 @default.
- W2030605887 creator A5036467945 @default.
- W2030605887 creator A5049546637 @default.
- W2030605887 creator A5067788379 @default.
- W2030605887 creator A5089392326 @default.
- W2030605887 creator A5089949394 @default.
- W2030605887 date "2007-10-29" @default.
- W2030605887 modified "2023-10-03" @default.
- W2030605887 title "Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin" @default.
- W2030605887 cites W1523852619 @default.
- W2030605887 cites W1557965441 @default.
- W2030605887 cites W1562339034 @default.
- W2030605887 cites W1776935265 @default.
- W2030605887 cites W1818502374 @default.
- W2030605887 cites W1819465909 @default.
- W2030605887 cites W1966009005 @default.
- W2030605887 cites W1969457486 @default.
- W2030605887 cites W1970555242 @default.
- W2030605887 cites W1977215885 @default.
- W2030605887 cites W1978927797 @default.
- W2030605887 cites W1979812872 @default.
- W2030605887 cites W1982838890 @default.
- W2030605887 cites W1987205815 @default.
- W2030605887 cites W2003641968 @default.
- W2030605887 cites W2007908049 @default.
- W2030605887 cites W2009651486 @default.
- W2030605887 cites W2009932721 @default.
- W2030605887 cites W2013306854 @default.
- W2030605887 cites W2017836030 @default.
- W2030605887 cites W2023135418 @default.
- W2030605887 cites W2023995540 @default.
- W2030605887 cites W2024803597 @default.
- W2030605887 cites W2047703509 @default.
- W2030605887 cites W2059610096 @default.
- W2030605887 cites W2059717547 @default.
- W2030605887 cites W2061903251 @default.
- W2030605887 cites W2064488492 @default.
- W2030605887 cites W2064811005 @default.
- W2030605887 cites W2069660824 @default.
- W2030605887 cites W2070853191 @default.
- W2030605887 cites W2072903725 @default.
- W2030605887 cites W2074444128 @default.
- W2030605887 cites W2074451273 @default.
- W2030605887 cites W2080879373 @default.
- W2030605887 cites W2087369502 @default.
- W2030605887 cites W2091124904 @default.
- W2030605887 cites W2091666217 @default.
- W2030605887 cites W2101201744 @default.
- W2030605887 cites W2101625949 @default.
- W2030605887 cites W2105815827 @default.
- W2030605887 cites W2106104578 @default.
- W2030605887 cites W2106799985 @default.
- W2030605887 cites W2115287428 @default.
- W2030605887 cites W2115536580 @default.
- W2030605887 cites W2120040647 @default.
- W2030605887 cites W2120046045 @default.
- W2030605887 cites W2122680576 @default.
- W2030605887 cites W2126149196 @default.
- W2030605887 cites W2128154787 @default.
- W2030605887 cites W2129319296 @default.
- W2030605887 cites W2130152738 @default.
- W2030605887 cites W2130649423 @default.
- W2030605887 cites W2136082432 @default.
- W2030605887 cites W2137221055 @default.
- W2030605887 cites W2137346267 @default.
- W2030605887 cites W2140433991 @default.
- W2030605887 cites W2150277507 @default.
- W2030605887 cites W2154044374 @default.
- W2030605887 cites W2156594133 @default.
- W2030605887 cites W2167437560 @default.
- W2030605887 cites W2170569505 @default.
- W2030605887 cites W2187720951 @default.
- W2030605887 cites W2319884815 @default.
- W2030605887 cites W2406855217 @default.
- W2030605887 cites W4233502188 @default.
- W2030605887 doi "https://doi.org/10.1084/jem.20071032" @default.
- W2030605887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118508" @default.
- W2030605887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17967904" @default.
- W2030605887 hasPublicationYear "2007" @default.
- W2030605887 type Work @default.
- W2030605887 sameAs 2030605887 @default.
- W2030605887 citedByCount "62" @default.
- W2030605887 countsByYear W20306058872012 @default.
- W2030605887 countsByYear W20306058872013 @default.
- W2030605887 countsByYear W20306058872014 @default.
- W2030605887 countsByYear W20306058872015 @default.
- W2030605887 countsByYear W20306058872017 @default.
- W2030605887 countsByYear W20306058872018 @default.
- W2030605887 countsByYear W20306058872019 @default.
- W2030605887 countsByYear W20306058872020 @default.
- W2030605887 countsByYear W20306058872021 @default.
- W2030605887 countsByYear W20306058872023 @default.