Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030607193> ?p ?o ?g. }
- W2030607193 endingPage "4356" @default.
- W2030607193 startingPage "4337" @default.
- W2030607193 abstract "Paclitaxel (PTX, taxol), a classical antitumor drug against a wide range of tumors, shows poor oral bioavailability. In order to improve the oral bioavailability of PTX, glycyrrhizic acid (GA) was used as the carrier in this study. This was the first report on the preparation, characterization and the pharmacokinetic study in rats of PTX-loaded GA micelles The PTX-loaded micelles, prepared with ultrasonic dispersion method, displayed small particle sizes and spherical shapes. Differential scanning calorimeter (DSC) thermograms indicated that PTX was entrapped in the GA micelles and existed as an amorphous state. The encapsulation efficiency was about 90%, and the drug loading rate could reach up to 7.90%. PTX-loaded GA micelles displayed a delayed drug release compared to Taxol in the in vitro release experiment. In pharmacokinetic study via oral administration, the area under the plasma concentration-time curve (AUC0→24 h) of PTX-loaded GA micelles was about six times higher than that of Taxol (p < 0.05). The significant oral absorption enhancement of PTX from PTX-loaded GA micelles could be largely due to the increased absorption in jejunum and colon intestine. All these results suggested that GA would be a promising carrier for the oral delivery of PTX." @default.
- W2030607193 created "2016-06-24" @default.
- W2030607193 creator A5015995069 @default.
- W2030607193 creator A5036267807 @default.
- W2030607193 creator A5046779498 @default.
- W2030607193 creator A5051507002 @default.
- W2030607193 creator A5052996378 @default.
- W2030607193 creator A5082084048 @default.
- W2030607193 creator A5086103528 @default.
- W2030607193 creator A5087089715 @default.
- W2030607193 date "2015-03-06" @default.
- W2030607193 modified "2023-10-05" @default.
- W2030607193 title "Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles" @default.
- W2030607193 cites W1540839883 @default.
- W2030607193 cites W1965912922 @default.
- W2030607193 cites W1970518854 @default.
- W2030607193 cites W1972132012 @default.
- W2030607193 cites W1973744073 @default.
- W2030607193 cites W1981178961 @default.
- W2030607193 cites W1981912612 @default.
- W2030607193 cites W1984820569 @default.
- W2030607193 cites W1990440677 @default.
- W2030607193 cites W2004732629 @default.
- W2030607193 cites W2009575431 @default.
- W2030607193 cites W2015934294 @default.
- W2030607193 cites W2020747873 @default.
- W2030607193 cites W2022069744 @default.
- W2030607193 cites W2024708440 @default.
- W2030607193 cites W2038093943 @default.
- W2030607193 cites W2041240538 @default.
- W2030607193 cites W2044280032 @default.
- W2030607193 cites W2044647958 @default.
- W2030607193 cites W2045830660 @default.
- W2030607193 cites W2048969741 @default.
- W2030607193 cites W2050668356 @default.
- W2030607193 cites W2054068500 @default.
- W2030607193 cites W2062047808 @default.
- W2030607193 cites W2062628487 @default.
- W2030607193 cites W2063108311 @default.
- W2030607193 cites W2066793708 @default.
- W2030607193 cites W2069360982 @default.
- W2030607193 cites W2069400447 @default.
- W2030607193 cites W2070588615 @default.
- W2030607193 cites W2072018844 @default.
- W2030607193 cites W2073061907 @default.
- W2030607193 cites W2077629580 @default.
- W2030607193 cites W2086647019 @default.
- W2030607193 cites W2090548281 @default.
- W2030607193 cites W2092370160 @default.
- W2030607193 cites W2092625982 @default.
- W2030607193 cites W2093030289 @default.
- W2030607193 cites W2103594523 @default.
- W2030607193 cites W2107629551 @default.
- W2030607193 cites W2130712377 @default.
- W2030607193 cites W2140733649 @default.
- W2030607193 cites W2144850839 @default.
- W2030607193 cites W2164169329 @default.
- W2030607193 cites W2166529317 @default.
- W2030607193 cites W2171071594 @default.
- W2030607193 cites W2359978783 @default.
- W2030607193 cites W2393054026 @default.
- W2030607193 doi "https://doi.org/10.3390/molecules20034337" @default.
- W2030607193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6272134" @default.
- W2030607193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25756651" @default.
- W2030607193 hasPublicationYear "2015" @default.
- W2030607193 type Work @default.
- W2030607193 sameAs 2030607193 @default.
- W2030607193 citedByCount "70" @default.
- W2030607193 countsByYear W20306071932016 @default.
- W2030607193 countsByYear W20306071932017 @default.
- W2030607193 countsByYear W20306071932018 @default.
- W2030607193 countsByYear W20306071932019 @default.
- W2030607193 countsByYear W20306071932020 @default.
- W2030607193 countsByYear W20306071932021 @default.
- W2030607193 countsByYear W20306071932022 @default.
- W2030607193 countsByYear W20306071932023 @default.
- W2030607193 crossrefType "journal-article" @default.
- W2030607193 hasAuthorship W2030607193A5015995069 @default.
- W2030607193 hasAuthorship W2030607193A5036267807 @default.
- W2030607193 hasAuthorship W2030607193A5046779498 @default.
- W2030607193 hasAuthorship W2030607193A5051507002 @default.
- W2030607193 hasAuthorship W2030607193A5052996378 @default.
- W2030607193 hasAuthorship W2030607193A5082084048 @default.
- W2030607193 hasAuthorship W2030607193A5086103528 @default.
- W2030607193 hasAuthorship W2030607193A5087089715 @default.
- W2030607193 hasBestOaLocation W20306071931 @default.
- W2030607193 hasConcept C11268172 @default.
- W2030607193 hasConcept C112705442 @default.
- W2030607193 hasConcept C125287762 @default.
- W2030607193 hasConcept C141071460 @default.
- W2030607193 hasConcept C159985019 @default.
- W2030607193 hasConcept C178790620 @default.
- W2030607193 hasConcept C181389837 @default.
- W2030607193 hasConcept C184651966 @default.
- W2030607193 hasConcept C185592680 @default.
- W2030607193 hasConcept C192562407 @default.
- W2030607193 hasConcept C2776694085 @default.
- W2030607193 hasConcept C2777292972 @default.