FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030617355> ?p ?o ?g. }

• W2030617355 endingPage "18" @default.
• W2030617355 startingPage "7" @default.
• W2030617355 abstract "BACKGROUND The ability to predict biologic behavior and treatment responsiveness would be a valuable asset in the multimodality approach to esophageal carcinoma. The authors examined whether alterations of the p53 gene correlate with clinicopathologic parameters, response to preoperative chemotherapy/radiotherapy, and outcome in patients with esophageal carcinoma. METHODS Histopathologic/genetic analysis of p53 was performed on formalin fixed, paraffin embedded tissues. Tissue sections were stained immunohistochemically for p53 protein followed by topographic genotyping comprised of polymerase chain reaction amplification and direct sequencing of p53 exons 5-8. All patients received induction chemotherapy (5-fluorouracil, cisplatin, and α-interferon) and concurrent external beam radiotherapy (4500 centigrays) followed by resection. RESULTS p53 analysis performed on 42 tumors from patients with potentially resectable esophageal carcinoma revealed 25 of the 42 tumors (59.5%) to be p53 immunopositive; however, only 17 of the 42 tumors (40.5%) were proven to contain p53 point mutational damage in exons 8 (n = 5), 5 (n = 5), 7 (n = 4), and 6 (n = 3). Eight cases were weakly immunopositive and had no genotype mutation suggesting hyperexpression of normal wild-type p53. Genotyping also identified two immunonegative cases with deletion-type mutations (exons 5 and 6). Tissue samples collected before and after chemotherapy/radiotherapy exhibited fidelity in p53 mutational genotype in all cases. The presence of a p53 point mutation positively correlated with pTNM stage (P = 0.003) and residual disease in the resected specimen (P = 0.01). Moreover, survival of patients with p53 mutations was significantly lower than that of patients without mutations (overall survival of 21.6 months vs. 40 months; P = 0.0038; and disease free survival of 14.1 months vs. 38 months; P = 0.0004). CONCLUSIONS Histopathologic/genetic analysis is a better determinant of p53 mutational damage than immunohistochemistry alone and can be used as a prognostic marker for esophageal carcinoma. p53 genotyping may define a subset of patients who respond to chemotherapy/radiotherapy and may predict who potentially benefits from multimodality therapy. Cancer 1998;83:7-18. © 1998 American Cancer Society." @default.
• W2030617355 created "2016-06-24" @default.
• W2030617355 creator A5017526826 @default.
• W2030617355 creator A5026778511 @default.
• W2030617355 creator A5067541948 @default.
• W2030617355 creator A5070231669 @default.
• W2030617355 creator A5074136570 @default.
• W2030617355 creator A5079335804 @default.
• W2030617355 creator A5079608944 @default.
• W2030617355 creator A5085005018 @default.
• W2030617355 creator A5088564762 @default.
• W2030617355 date "1998-07-01" @default.
• W2030617355 modified "2023-10-15" @default.
• W2030617355 title "p53 sequence analysis predicts treatment response and outcome of patients with esophageal carcinoma" @default.
• W2030617355 cites W1819031394 @default.
• W2030617355 cites W1859397449 @default.
• W2030617355 cites W1908474666 @default.
• W2030617355 cites W1947407197 @default.
• W2030617355 cites W1967158462 @default.
• W2030617355 cites W1968351606 @default.
• W2030617355 cites W1974145895 @default.
• W2030617355 cites W1974541194 @default.
• W2030617355 cites W1982619204 @default.
• W2030617355 cites W1982706487 @default.
• W2030617355 cites W1988756673 @default.
• W2030617355 cites W1995641241 @default.
• W2030617355 cites W1997034463 @default.
• W2030617355 cites W2001258296 @default.
• W2030617355 cites W2011189845 @default.
• W2030617355 cites W2011771973 @default.
• W2030617355 cites W2012053348 @default.
• W2030617355 cites W2017467516 @default.
• W2030617355 cites W2031404936 @default.
• W2030617355 cites W2033322610 @default.
• W2030617355 cites W2033374677 @default.
• W2030617355 cites W2034639401 @default.
• W2030617355 cites W2038686723 @default.
• W2030617355 cites W2041442073 @default.
• W2030617355 cites W2042316019 @default.
• W2030617355 cites W2051619281 @default.
• W2030617355 cites W2054022640 @default.
• W2030617355 cites W2054549064 @default.
• W2030617355 cites W2058183718 @default.
• W2030617355 cites W2060937867 @default.
• W2030617355 cites W2065505484 @default.
• W2030617355 cites W2067484068 @default.
• W2030617355 cites W2068622871 @default.
• W2030617355 cites W2070051352 @default.
• W2030617355 cites W2070419431 @default.
• W2030617355 cites W2078581194 @default.
• W2030617355 cites W2078899066 @default.
• W2030617355 cites W2084314047 @default.
• W2030617355 cites W2090157013 @default.
• W2030617355 cites W2094699565 @default.
• W2030617355 cites W2096383691 @default.
• W2030617355 cites W2096428903 @default.
• W2030617355 cites W2101015327 @default.
• W2030617355 cites W2111761059 @default.
• W2030617355 cites W2134198701 @default.
• W2030617355 cites W2148153630 @default.
• W2030617355 cites W2162182530 @default.
• W2030617355 cites W2162368186 @default.
• W2030617355 cites W2163565167 @default.
• W2030617355 cites W2165314624 @default.
• W2030617355 cites W2178272638 @default.
• W2030617355 cites W2301471934 @default.
• W2030617355 cites W2403796793 @default.
• W2030617355 cites W2461092061 @default.
• W2030617355 cites W4210976695 @default.
• W2030617355 doi "https://doi.org/10.1002/(sici)1097-0142(19980701)83:1<7::aid-cncr2>3.0.co;2-r" @default.
• W2030617355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9655287" @default.
• W2030617355 hasPublicationYear "1998" @default.
• W2030617355 type Work @default.
• W2030617355 sameAs 2030617355 @default.
• W2030617355 citedByCount "132" @default.
• W2030617355 countsByYear W20306173552012 @default.
• W2030617355 countsByYear W20306173552013 @default.
• W2030617355 countsByYear W20306173552014 @default.
• W2030617355 countsByYear W20306173552015 @default.
• W2030617355 countsByYear W20306173552016 @default.
• W2030617355 countsByYear W20306173552017 @default.
• W2030617355 countsByYear W20306173552018 @default.
• W2030617355 countsByYear W20306173552019 @default.
• W2030617355 countsByYear W20306173552021 @default.
• W2030617355 countsByYear W20306173552022 @default.
• W2030617355 crossrefType "journal-article" @default.
• W2030617355 hasAuthorship W2030617355A5017526826 @default.
• W2030617355 hasAuthorship W2030617355A5026778511 @default.
• W2030617355 hasAuthorship W2030617355A5067541948 @default.
• W2030617355 hasAuthorship W2030617355A5070231669 @default.
• W2030617355 hasAuthorship W2030617355A5074136570 @default.
• W2030617355 hasAuthorship W2030617355A5079335804 @default.
• W2030617355 hasAuthorship W2030617355A5079608944 @default.
• W2030617355 hasAuthorship W2030617355A5085005018 @default.
• W2030617355 hasAuthorship W2030617355A5088564762 @default.
• W2030617355 hasBestOaLocation W20306173551 @default.
• W2030617355 hasConcept C104317684 @default.
• W2030617355 hasConcept C11242284 @default.

• next