FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030619130> ?p ?o ?g. }

• W2030619130 abstract "In these studies, the inhibitory role of a large granular lymphocyte (LGL) subset (CD5-,CD16+) on pokeweed mitogen (PWM)-induced B lymphocyte differentiation was examined. CD5-,CD16+ LGL cells are the predominant subset of LGL cells and are possibly distinct from other LGL subsets in that they lack B and T cell markers. CD5-,CD16+ LGL possess abundant FcIgG receptors and previous studies have clearly demonstrated that in the presence of insoluble immune complexes, this LGL subset will inhibit B lymphocyte differentiation in the presence of T cells. In the present studies, we analyzed the inhibiting role of CD5-,CD16+ LGL cells that had not been activated by immune complexes. B + L preparations obtained by removal of E rosette-forming T cells were further depleted of T lymphocytes by complement-dependent lysis of T cells using a monoclonal antibody reactive to total T cells (Leu-1, CD5 antigen, Becton-Dickinson). B lymphocytes in such B + L preparations failed to differentiate into plasma cells containing intracytoplasmic immunoglobulin (Ig), in the presence of PWM, T cell-derived helper supernatants (THS), and interleukin-2 (IL-2). However, B cells differentiated under these conditions, when B + L preparations were further depleted of CD5-,CD16+ LGL cells by complement-dependent lysis using a monoclonal antibody (Leu-11) reactive to CD16 antigen of FcIgG receptors present on LGL cells. These studies indicated that CD5-,CD16+ cells unlike the CD8-positive T suppressor cell, will directly inhibit B lymphocyte differentiation into plasmacytoid cells containing intracytoplasmic Ig when T lymphocytes are not present. However, addition of a few T lymphocytes (less than 10%) to purified B + L preparations abrogated the CD5-,CD16+ LGL cell inhibition of B cell differentiation." @default.
• W2030619130 created "2016-06-24" @default.
• W2030619130 creator A5002436965 @default.
• W2030619130 creator A5068352746 @default.
• W2030619130 date "1988-12-01" @default.
• W2030619130 modified "2023-09-26" @default.
• W2030619130 title "In vitro assays to study role of T cell-derived factors on human B lymphocytes should take into consideration inhibiting effect of large granular lymphocyte subset (CD5−,CD16+) that can contaminate B cell preparations" @default.
• W2030619130 cites W1489355697 @default.
• W2030619130 cites W1504875452 @default.
• W2030619130 cites W1553692071 @default.
• W2030619130 cites W1564599513 @default.
• W2030619130 cites W1571911874 @default.
• W2030619130 cites W1572905821 @default.
• W2030619130 cites W1584296279 @default.
• W2030619130 cites W1585147909 @default.
• W2030619130 cites W1665947150 @default.
• W2030619130 cites W1771231716 @default.
• W2030619130 cites W1894495795 @default.
• W2030619130 cites W1913814259 @default.
• W2030619130 cites W2045828382 @default.
• W2030619130 cites W2052214675 @default.
• W2030619130 cites W2086176855 @default.
• W2030619130 cites W2118205899 @default.
• W2030619130 cites W2123044527 @default.
• W2030619130 cites W2125622276 @default.
• W2030619130 cites W2161082695 @default.
• W2030619130 cites W2187251667 @default.
• W2030619130 doi "https://doi.org/10.1016/0022-1759(88)90293-1" @default.
• W2030619130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3264313" @default.
• W2030619130 hasPublicationYear "1988" @default.
• W2030619130 type Work @default.
• W2030619130 sameAs 2030619130 @default.
• W2030619130 citedByCount "5" @default.
• W2030619130 crossrefType "journal-article" @default.
• W2030619130 hasAuthorship W2030619130A5002436965 @default.
• W2030619130 hasAuthorship W2030619130A5068352746 @default.
• W2030619130 hasConcept C113067387 @default.
• W2030619130 hasConcept C114684123 @default.
• W2030619130 hasConcept C147483822 @default.
• W2030619130 hasConcept C153911025 @default.
• W2030619130 hasConcept C154317977 @default.
• W2030619130 hasConcept C159654299 @default.
• W2030619130 hasConcept C167672396 @default.
• W2030619130 hasConcept C202751555 @default.
• W2030619130 hasConcept C203014093 @default.
• W2030619130 hasConcept C2777761686 @default.
• W2030619130 hasConcept C2778453870 @default.
• W2030619130 hasConcept C2781462264 @default.
• W2030619130 hasConcept C55493867 @default.
• W2030619130 hasConcept C86803240 @default.
• W2030619130 hasConceptScore W2030619130C113067387 @default.
• W2030619130 hasConceptScore W2030619130C114684123 @default.
• W2030619130 hasConceptScore W2030619130C147483822 @default.
• W2030619130 hasConceptScore W2030619130C153911025 @default.
• W2030619130 hasConceptScore W2030619130C154317977 @default.
• W2030619130 hasConceptScore W2030619130C159654299 @default.
• W2030619130 hasConceptScore W2030619130C167672396 @default.
• W2030619130 hasConceptScore W2030619130C202751555 @default.
• W2030619130 hasConceptScore W2030619130C203014093 @default.
• W2030619130 hasConceptScore W2030619130C2777761686 @default.
• W2030619130 hasConceptScore W2030619130C2778453870 @default.
• W2030619130 hasConceptScore W2030619130C2781462264 @default.
• W2030619130 hasConceptScore W2030619130C55493867 @default.
• W2030619130 hasConceptScore W2030619130C86803240 @default.
• W2030619130 hasLocation W20306191301 @default.
• W2030619130 hasLocation W20306191302 @default.
• W2030619130 hasOpenAccess W2030619130 @default.
• W2030619130 hasPrimaryLocation W20306191301 @default.
• W2030619130 hasRelatedWork W119517883 @default.
• W2030619130 hasRelatedWork W1196912039 @default.
• W2030619130 hasRelatedWork W1570611950 @default.
• W2030619130 hasRelatedWork W1964681740 @default.
• W2030619130 hasRelatedWork W1973296161 @default.
• W2030619130 hasRelatedWork W2065169027 @default.
• W2030619130 hasRelatedWork W2317168280 @default.
• W2030619130 hasRelatedWork W2462261790 @default.
• W2030619130 hasRelatedWork W2474448634 @default.
• W2030619130 hasRelatedWork W339756260 @default.
• W2030619130 isParatext "false" @default.
• W2030619130 isRetracted "false" @default.
• W2030619130 magId "2030619130" @default.
• W2030619130 workType "article" @default.