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• W2030620933 abstract "Cyclic stretch is an artificial model of mechanical force loading, which induces the reorientation of vascular endothelial cells (ECs) and their stress fibers in a direction perpendicular to the stretch axis. Rho family GTPases are crucial for cyclic stretch-induced EC reorientation; however, the mechanism underlying stretch-induced activation of Rho family GTPases is unknown. A screen of short-hairpin RNAs targeting 63 Rho-guanine nucleotide exchange factors (Rho-GEFs) revealed that at least 11 Rho-GEFs (Abr, Alsin, ARHGEF10, Bcr, GEF-H1, LARG, p190RhoGEF, PLEKHG1, P-REX2, Solo/ARHGEF40, and α-PIX), which specifically or broadly target RhoA, Rac1 and/or Cdc42, are involved in cyclic stretch-induced perpendicular reorientation of ECs. Overexpression of Solo induced RhoA activation and F-actin accumulation at cell-cell and cell-substrate adhesion sites. Knockdown of Solo suppressed cyclic stretch- or tensile force-induced RhoA activation. Moreover, knockdown of Solo significantly reduced cyclic stretch-induced perpendicular reorientation of ECs when cells were cultured at high density, but not when they were cultured at low density or pretreated with EGTA or VE-cadherin-targeting siRNAs. These results suggest that Solo is involved in cell-cell adhesion-mediated mechanical signal transduction during cyclic stretch-induced EC reorientation." @default.
• W2030620933 created "2016-06-24" @default.
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• W2030620933 date "2015-01-01" @default.
• W2030620933 modified "2023-10-17" @default.
• W2030620933 title "Rho-guanine nucleotide exchange factors involved in cyclic stretch-induced reorientation of vascular endothelial cells" @default.
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• W2030620933 doi "https://doi.org/10.1242/jcs.157503" @default.
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