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• W2030622562 abstract "ObjectiveAlthough there are some genetic studies reported about relationship between endometriosis and genetic polymorphisms, the exact genes responsible for the pathophysiology of endometriosis still remains unclear. We want to investigate whether polymorphisms of CYP17 and CYP19 genes may be associated with the presence of endometriosis.DesignProspective, case control study.Materials and methodsIn this study, 50 and 43 cases were included in endometriosis group and control group, respectively. The diagnosis of patients with endometriosis were confirmed by laparoscopy or laparotomy and staged according to the revised ASRM classification. Although, the diagnosis were visually confirmed in the cases of early staged endometriosis; both surgical and hystopathological diagnosis were performed in patients with advanced stage. The control group was selected between the cases that have any estrogen-related disease (myoma, endometriosis, endometrioma, endometrial cancer, and breast cancer). The absence of estrogen related diseases was excluded by detailed history, physical-pelvic examination, ultrasonographic assessment and surgical exploration. In control group, laparoscopic surgical explorations were performed due to gynecological reasons such as pelvic pain or tubal sterilization. Following isolation of DNA from collected peripheral blood samples, cryopreservation of the specimens at -20°C was performed. The Lightcycler PCR (polymerase chain reaction) analyses were carried out after the collection of all samples. The 50 patients in endometriosis group and 43 cases in control group were examined for the presence of CYP19 (F3, F2) and CYP17 (A1A2, A2A2) gene polymorphisms. Pearson Chi-square and Fisher’s exact test were performed for statistical analysis.ResultsTabled 1ConclusionsAlthough it did not reach a significant level, the rate of the presence of CYP19 F2-F3 gene polymorphism seems to be higher in endometriosis group (%16.3) when compared with controls (%22) (p>0.05). However, the rate of the presence of CYP17 A2A2 polymorphism is significantly higher in patients with endometriosis when compared with control group (48.0 vs 20.9%, p=0.01). These results may suggest a possible relationship between genetic disorders and endometriosis. ObjectiveAlthough there are some genetic studies reported about relationship between endometriosis and genetic polymorphisms, the exact genes responsible for the pathophysiology of endometriosis still remains unclear. We want to investigate whether polymorphisms of CYP17 and CYP19 genes may be associated with the presence of endometriosis. Although there are some genetic studies reported about relationship between endometriosis and genetic polymorphisms, the exact genes responsible for the pathophysiology of endometriosis still remains unclear. We want to investigate whether polymorphisms of CYP17 and CYP19 genes may be associated with the presence of endometriosis. DesignProspective, case control study. Prospective, case control study. Materials and methodsIn this study, 50 and 43 cases were included in endometriosis group and control group, respectively. The diagnosis of patients with endometriosis were confirmed by laparoscopy or laparotomy and staged according to the revised ASRM classification. Although, the diagnosis were visually confirmed in the cases of early staged endometriosis; both surgical and hystopathological diagnosis were performed in patients with advanced stage. The control group was selected between the cases that have any estrogen-related disease (myoma, endometriosis, endometrioma, endometrial cancer, and breast cancer). The absence of estrogen related diseases was excluded by detailed history, physical-pelvic examination, ultrasonographic assessment and surgical exploration. In control group, laparoscopic surgical explorations were performed due to gynecological reasons such as pelvic pain or tubal sterilization. Following isolation of DNA from collected peripheral blood samples, cryopreservation of the specimens at -20°C was performed. The Lightcycler PCR (polymerase chain reaction) analyses were carried out after the collection of all samples. The 50 patients in endometriosis group and 43 cases in control group were examined for the presence of CYP19 (F3, F2) and CYP17 (A1A2, A2A2) gene polymorphisms. Pearson Chi-square and Fisher’s exact test were performed for statistical analysis. In this study, 50 and 43 cases were included in endometriosis group and control group, respectively. The diagnosis of patients with endometriosis were confirmed by laparoscopy or laparotomy and staged according to the revised ASRM classification. Although, the diagnosis were visually confirmed in the cases of early staged endometriosis; both surgical and hystopathological diagnosis were performed in patients with advanced stage. The control group was selected between the cases that have any estrogen-related disease (myoma, endometriosis, endometrioma, endometrial cancer, and breast cancer). The absence of estrogen related diseases was excluded by detailed history, physical-pelvic examination, ultrasonographic assessment and surgical exploration. In control group, laparoscopic surgical explorations were performed due to gynecological reasons such as pelvic pain or tubal sterilization. Following isolation of DNA from collected peripheral blood samples, cryopreservation of the specimens at -20°C was performed. The Lightcycler PCR (polymerase chain reaction) analyses were carried out after the collection of all samples. The 50 patients in endometriosis group and 43 cases in control group were examined for the presence of CYP19 (F3, F2) and CYP17 (A1A2, A2A2) gene polymorphisms. Pearson Chi-square and Fisher’s exact test were performed for statistical analysis. ResultsTabled 1 ConclusionsAlthough it did not reach a significant level, the rate of the presence of CYP19 F2-F3 gene polymorphism seems to be higher in endometriosis group (%16.3) when compared with controls (%22) (p>0.05). However, the rate of the presence of CYP17 A2A2 polymorphism is significantly higher in patients with endometriosis when compared with control group (48.0 vs 20.9%, p=0.01). These results may suggest a possible relationship between genetic disorders and endometriosis. Although it did not reach a significant level, the rate of the presence of CYP19 F2-F3 gene polymorphism seems to be higher in endometriosis group (%16.3) when compared with controls (%22) (p>0.05). However, the rate of the presence of CYP17 A2A2 polymorphism is significantly higher in patients with endometriosis when compared with control group (48.0 vs 20.9%, p=0.01). These results may suggest a possible relationship between genetic disorders and endometriosis." @default.
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• W2030622562 title "Detection of CYP17 and CYP19 Gene Polymorphisms in Endometriosis" @default.
• W2030622562 doi "https://doi.org/10.1016/j.fertnstert.2005.07.507" @default.
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