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- W2030626907 abstract "The Zucker diabetic fatty rat (ZDFGmi-fa), a model for noninsulin-dependent diabetes mellitus (NIDDM), was used to evaluate the action of dietary acarbose (20 week, 40 mg/100 g diet) in improving hyperglycemia. Muscle glucose uptake and glucose transport were measured during hindlimb perfusion. GLUT4 protein was also measured in the perfused muscle. Insulin resistance was not observed in skeletal muscle from diabetic animals compared with lean controls as concluded from equivalent hemicorpus glucose uptake and muscle glucose transport rates. Three fold increases in both GLUT4 protein and glucose transport were observed in acarbose-fed lean rats compared with lean controls. Acarbose feeding significantly decreased hyperglycemia in diabetic rats. This improvement seems not to be the result of an increase in insulin-stimulated glucose transport in muscle as insulin sensitivity and responsiveness were unchanged." @default.
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- W2030626907 title "Effects of feeding acarbose on muscle glucose transport and GLUT4 protein in lean and obese diabetic (ZDFGmi-fa) rats" @default.
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