FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030636745> ?p ?o ?g. }

• W2030636745 endingPage "940" @default.
• W2030636745 startingPage "925" @default.
• W2030636745 abstract "Glutamatergic and GABAergic responses of the neostriatal spiny neurons to intrastriatal and cortical stimulation were characterized by intracellular recording in brain slice preparations. This study also demonstrated the role of each response in the spike activity of the spiny neuron. Single neostriatal stimulation induced postsynaptic potentials consisting of multiple components. The early part of the postsynaptic potential, which was isolated by the GABAA antagonist bicuculline methiodide and the N-methyl-d-aspartate antagonist 3-(2-carboxypiperzin-4-yl)-propyl-1-phosphonic acid (CPP), was mainly an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate receptor-mediated response. Perfusion of magnesium-free medium containing bicuculline methiodide and the AMPA/kainate antagonist 3-dihydroxy-6-nitro-7-sulfamoyl-benzo]f]quinoxaline (NBQX) disclosed a large, slow N-methyl-d-aspartate receptor-mediated response. the N-methyl-d-aspartate response in magnesium-containing perfusing medium was small in neurons at the resting membrane potential, but became a significant component when the neurons were depolarized to subthreshold membrane potential. The duration of the N-methyl-d-aspartate response was over 300 ms. The nicotinic antagonists dihydro-β-erythroidine hydrobromide and mecamylamine failed to change responses to single stimulation. Repetitive intrastriatal stimulation induced a large, long-duration depolarization with action potentials in the spiny neurons. This stimulation-induced response resembles that of the depolarization stage observed in anesthetized animals. Bicuculline methiodide increased the response amplitude. In contrast, CPP reduced the amplitude of the response to the below the spike generation threshold. The CPP-sensitive N-methyl-d-aspartate response was large and lasted several hundred milliseconds after the termination of repetitive stimulation. Responses of the neostriatal neurons to cortical stimulation were similar to those induced after intrastriatal stimulation. CPP greatly reduced both the response amplitude and the number of spikes triggered from the response. Bicuculline methiodide, on the other hand, greatly increased the response amplitude and the number of spikes. The AMPA/kainate response alone, which was isolated by application of bicuculline methiodide and CPP, did not induce sustained depolarization in spiny neurons to repetitive cortical stimulation. Application of NBQX diminished GABAA response to cortical stimulation. This observation indicates that, for neostriatal spiny neurons to respond with GABAA response after cortical stimulation, the AMPA/kainate response must be induced in the GABAergic secondary neurons in the neostriatum. This study indicates that the main synaptic driving forces of neostriatal spiny neurons include AMPA/kainate, N-methyl-d-aspartate and GABAA responses. Although AMPA/kainate response is the main synaptic input, the generation of the action potentials in neostriatal neurons is greatly influenced by both GABAA and N-methyl-d-aspartate responses." @default.
• W2030636745 created "2016-06-24" @default.
• W2030636745 creator A5066391585 @default.
• W2030636745 date "1996-02-01" @default.
• W2030636745 modified "2023-10-18" @default.
• W2030636745 title "Glutamatergic and gabaergic postsynaptic responses of striatal spiny neurons to intrastriatal and cortical stimulation recorded in slice preparations" @default.
• W2030636745 cites W1595473599 @default.
• W2030636745 cites W1622774380 @default.
• W2030636745 cites W1660355078 @default.
• W2030636745 cites W1774047354 @default.
• W2030636745 cites W1823632716 @default.
• W2030636745 cites W1910271824 @default.
• W2030636745 cites W1963569120 @default.
• W2030636745 cites W1964108939 @default.
• W2030636745 cites W1969109219 @default.
• W2030636745 cites W1971692666 @default.
• W2030636745 cites W1974183957 @default.
• W2030636745 cites W1978112166 @default.
• W2030636745 cites W1984770449 @default.
• W2030636745 cites W1989809574 @default.
• W2030636745 cites W1997568797 @default.
• W2030636745 cites W1998347917 @default.
• W2030636745 cites W2006457780 @default.
• W2030636745 cites W2009197173 @default.
• W2030636745 cites W2011532922 @default.
• W2030636745 cites W2012064273 @default.
• W2030636745 cites W2015305099 @default.
• W2030636745 cites W2020227900 @default.
• W2030636745 cites W2025125621 @default.
• W2030636745 cites W2026389621 @default.
• W2030636745 cites W2036575624 @default.
• W2030636745 cites W2037402570 @default.
• W2030636745 cites W2044035733 @default.
• W2030636745 cites W2051475820 @default.
• W2030636745 cites W2052405932 @default.
• W2030636745 cites W2056807205 @default.
• W2030636745 cites W2057073173 @default.
• W2030636745 cites W2060536994 @default.
• W2030636745 cites W2067796871 @default.
• W2030636745 cites W2068230856 @default.
• W2030636745 cites W2068765902 @default.
• W2030636745 cites W2070933799 @default.
• W2030636745 cites W2071563998 @default.
• W2030636745 cites W2085050072 @default.
• W2030636745 cites W2086730222 @default.
• W2030636745 cites W2093734160 @default.
• W2030636745 cites W2094167907 @default.
• W2030636745 cites W2108712999 @default.
• W2030636745 cites W2115444744 @default.
• W2030636745 cites W2121624942 @default.
• W2030636745 cites W2122946342 @default.
• W2030636745 cites W2129557089 @default.
• W2030636745 cites W2142009737 @default.
• W2030636745 cites W2144693928 @default.
• W2030636745 cites W2145213346 @default.
• W2030636745 cites W2157544393 @default.
• W2030636745 cites W2166067930 @default.
• W2030636745 cites W2395559438 @default.
• W2030636745 cites W2407000226 @default.
• W2030636745 cites W2413513126 @default.
• W2030636745 doi "https://doi.org/10.1016/0306-4522(95)00410-6" @default.
• W2030636745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8848174" @default.
• W2030636745 hasPublicationYear "1996" @default.
• W2030636745 type Work @default.
• W2030636745 sameAs 2030636745 @default.
• W2030636745 citedByCount "154" @default.
• W2030636745 countsByYear W20306367452013 @default.
• W2030636745 countsByYear W20306367452014 @default.
• W2030636745 countsByYear W20306367452015 @default.
• W2030636745 countsByYear W20306367452016 @default.
• W2030636745 countsByYear W20306367452017 @default.
• W2030636745 countsByYear W20306367452018 @default.
• W2030636745 countsByYear W20306367452019 @default.
• W2030636745 countsByYear W20306367452021 @default.
• W2030636745 crossrefType "journal-article" @default.
• W2030636745 hasAuthorship W2030636745A5066391585 @default.
• W2030636745 hasConcept C112592302 @default.
• W2030636745 hasConcept C160268369 @default.
• W2030636745 hasConcept C168258287 @default.
• W2030636745 hasConcept C169760540 @default.
• W2030636745 hasConcept C170493617 @default.
• W2030636745 hasConcept C17077164 @default.
• W2030636745 hasConcept C185592680 @default.
• W2030636745 hasConcept C189184402 @default.
• W2030636745 hasConcept C197341189 @default.
• W2030636745 hasConcept C24998067 @default.
• W2030636745 hasConcept C2778187257 @default.
• W2030636745 hasConcept C2779803574 @default.
• W2030636745 hasConcept C2780763569 @default.
• W2030636745 hasConcept C529278444 @default.
• W2030636745 hasConcept C55493867 @default.
• W2030636745 hasConcept C67018056 @default.
• W2030636745 hasConcept C85714458 @default.
• W2030636745 hasConcept C86803240 @default.
• W2030636745 hasConceptScore W2030636745C112592302 @default.
• W2030636745 hasConceptScore W2030636745C160268369 @default.
• W2030636745 hasConceptScore W2030636745C168258287 @default.
• W2030636745 hasConceptScore W2030636745C169760540 @default.

• next