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- W2030638034 abstract "<h3>Background:</h3> <i>Bartonella henselae</i>(formerly the genus<i>Rochalimaea</i>) has recently been isolated from patients with cat-scratch disease and their cats, and since September 1992 the Centers for Disease Control and Prevention has offered an indirect fluorescent antibody assay for<i>Bartonella</i>-specific antibody. <h3>Methods:</h3> Physicians submitted serum samples from patients suspected of having cat-scratch disease or other<i>Bartonella</i>-associated illness and completed a questionnaire that recorded clinical information. Indirect fluorescent antibody assay was performed with the use of antigen derived from three<i>Bartonella</i>species:<i>B henselae, Bartonella quintana</i>, and<i>Bartonella elizabethae</i>. <h3>Results:</h3> During 16 months, 3088 serum samples were received. The largest numbers of specimens and the highest percentages positive (titer, ≥64) were observed in the fall and winter. Clinical histories of the first 600 patients for whom serum samples and completed information forms were received were examined in detail; seropositivity was significantly associated with cat contact, cat age of less than 1 year, cat scratch, presence of an inoculation papule, and regional adenopathy. Of 91 patients whose illness met a strict clinical definition of cat-scratch disease, 86 (95%) had titers of 64 or greater to either<i>B henselae</i>or<i>B quintana</i>. A fourfold rise or fall in titer was observed in 87 of 132 patients with paired serum samples. <h3>Conclusions:</h3> The indirect fluorescent antibody assay for<sup>Bartonella</sup>-specific antibody is sensitive for the diagnosis of cat-scratch disease. Redefinition of cat-scratch disease on the basis of cause and use of this assay as a diagnostic criterion is recommended. (Arch Intern Med. 1995;155:1670-1676)" @default.
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- W2030638034 date "1995-08-07" @default.
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- W2030638034 title "Use of Bartonella Antigens for Serologic Diagnosis of Cat-scratch Disease at a National Referral Center" @default.
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- W2030638034 doi "https://doi.org/10.1001/archinte.1995.00430150164017" @default.
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