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• W2030657267 abstract "Tat is a major regulatory protein encoded by human immunodeficiency viral genome, which has been implicated in the pathogenesis of HIV infection, including neurologic complications associated with this disease. In addition, drug abuse has been identified as a major risk factor of HIV infection. We hypothesize that abusive drugs, such as methamphetamine (METH), can directly influence specific molecular processes that can further contribute to toxic effects of Tat. To elucidate the molecular signaling pathways of Tat- and/or METH-induced toxicity, we investigated the effects of a single injection of Tat (25 microg/microl into the right hippocampus) and/or METH (10 mg/kg, intraperitoneally) on the generation of cellular oxidative stress, DNA-binding activity of specific redox-responsive transcription factors, and expression of inflammatory genes. Administration of Tat or METH resulted in stimulation of cellular oxidative stress and activation of redox-regulated transcription factors in the cortical, striatal, and hippocampal regions of the mouse brain. In addition, DNA-binding activities of NF-kappaB, AP-1, and CREB in the frontal cortex and hippocampus were more pronounced in mice injected with Tat plus METH compared to the effects of Tat or METH alone. Intercellular adhesion molecule-1 gene expression also was upregulated in a synergistic manner in cortical, striatal, and hippocampal regions in mice which received injections of Tat combined with METH compared to the effects of these agents alone. Moreover, synergistic effects of Tat plus METH on the tumor necrosis factor-alpha and interleukin-1beta mRNA levels were observed in the striatal region. These results indicate that Tat and METH can cross-amplify their cellular effects, leading to alterations of redox-regulated inflammatory pathways in the brain. Such synergistic proinflammatory stimulation may have significant implications in HIV-infected patients who abuse drugs." @default.
• W2030657267 created "2016-06-24" @default.
• W2030657267 creator A5000097172 @default.
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• W2030657267 date "2003-01-01" @default.
• W2030657267 modified "2023-10-11" @default.
• W2030657267 title "Methamphetamine Potentiates HIV-1 Tat Protein-Mediated Activation of Redox-Sensitive Pathways in Discrete Regions of the Brain" @default.
• W2030657267 cites W1490582338 @default.
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• W2030657267 cites W1524845305 @default.
• W2030657267 cites W1542501108 @default.
• W2030657267 cites W1560943379 @default.
• W2030657267 cites W1583492957 @default.
• W2030657267 cites W1588570886 @default.
• W2030657267 cites W1590514634 @default.
• W2030657267 cites W1684853394 @default.
• W2030657267 cites W1894689389 @default.
• W2030657267 cites W1905628010 @default.
• W2030657267 cites W1964226908 @default.
• W2030657267 cites W1969249644 @default.
• W2030657267 cites W1974271654 @default.
• W2030657267 cites W1979861012 @default.
• W2030657267 cites W1982886442 @default.
• W2030657267 cites W1985924253 @default.
• W2030657267 cites W1988949532 @default.
• W2030657267 cites W1996286392 @default.
• W2030657267 cites W2003622444 @default.
• W2030657267 cites W2017165365 @default.
• W2030657267 cites W2018443033 @default.
• W2030657267 cites W2021479980 @default.
• W2030657267 cites W2022683869 @default.
• W2030657267 cites W2024667031 @default.
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• W2030657267 cites W2043390267 @default.
• W2030657267 cites W2047291062 @default.
• W2030657267 cites W2049384855 @default.
• W2030657267 cites W2055338293 @default.
• W2030657267 cites W2062821281 @default.
• W2030657267 cites W2065235584 @default.
• W2030657267 cites W2068211039 @default.
• W2030657267 cites W2071895590 @default.
• W2030657267 cites W2073422014 @default.
• W2030657267 cites W2073424517 @default.
• W2030657267 cites W2077395194 @default.
• W2030657267 cites W2084240094 @default.
• W2030657267 cites W2085612389 @default.
• W2030657267 cites W2087044031 @default.
• W2030657267 cites W2087296412 @default.
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• W2030657267 cites W2104324075 @default.
• W2030657267 cites W2105896882 @default.
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• W2030657267 cites W2133850147 @default.
• W2030657267 cites W2136505680 @default.
• W2030657267 cites W2136565900 @default.
• W2030657267 cites W2142541950 @default.
• W2030657267 cites W2142580865 @default.
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• W2030657267 cites W2153531540 @default.
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• W2030657267 doi "https://doi.org/10.1006/exnr.2002.8048" @default.
• W2030657267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12504868" @default.
• W2030657267 hasPublicationYear "2003" @default.
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