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• W2030688085 abstract "This study examined age-dependent deficits in the learning and memory of fear conditioning, using a newly developed senescence-accelerated mouse (SAMP8) model of age-related brain dysfunction and its genetically related inbred strain (SAMR1). The mice were classically conditioned to tone by giving aversive foot shocks in a distinct experimental box (context). After conditioning, fear in response to the original context without the tone and to the tone in a different context were tested with no shocks. Freezing behavior was used as a reliable index of fear. At 4 and 8 months, contextual fear was weaker in the accelerated senescence-prone SAMP8 mice than in the accelerated senescence-resistant SAMR1 mice. However, at 1 and 2 months, both SAMP8 and SAMR1 mice showed significant contextual fear to equivalent levels. Aging did not affect the fear response to tone. These results indicate that SAMP8 mice have age-related learning and memory deficits in their fear response evoked by contextual but not explicit tone stimuli. Age-related hippocampal dysfunction is suggested to be the cause of these age-related deficits in contextual fear conditioning in SAMP8 mice." @default.
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• W2030688085 date "2001-05-01" @default.
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• W2030688085 title "Deterioration in learning and memory of fear conditioning in response to context in aged SAMP8 mice 1 1Abbreviations: SAM, senescence-accelerated mouse; SAMP, senescence-accelerated mouse prone; SAMR, senescence-accelerated mouse resistant; GABA, gamma-aminobutyric acid; MGRF, magnocelluar reticular formation; RSA, hippocampal rhythmic slow activity; CS, conditioned stimulus." @default.
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• W2030688085 doi "https://doi.org/10.1016/s0197-4580(01)00206-8" @default.
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