FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030692238> ?p ?o ?g. }

• W2030692238 endingPage "20882" @default.
• W2030692238 startingPage "20877" @default.
• W2030692238 abstract "Escherichia coli infections, a leading cause of septic shock, remain a major threat to human health because of the fatal action to endotoxin (LPS). Therapeutic attempts to neutralize endotoxin currently focus on inhibiting the interaction of the toxic component lipid A with myeloid differentiating factor 2, which forms a trimeric complex together with Toll-like receptor 4 to induce immune cell activation. The 1.73-Å resolution structure of the unique endotoxin-neutralizing protective antibody WN1 222-5 in complex with the core region shows that it recognizes LPS of all E. coli serovars in a manner similar to Toll-like receptor 4, revealing that protection can be achieved by targeting the inner core of LPS and that recognition of lipid A is not required. Such interference with Toll-like receptor complex formation opens new paths for antibody sepsis therapy independent of lipid A antagonists." @default.
• W2030692238 created "2016-06-24" @default.
• W2030692238 creator A5019622792 @default.
• W2030692238 creator A5027494787 @default.
• W2030692238 creator A5040792982 @default.
• W2030692238 creator A5044809005 @default.
• W2030692238 creator A5050261718 @default.
• W2030692238 creator A5058650693 @default.
• W2030692238 creator A5060473928 @default.
• W2030692238 creator A5074839838 @default.
• W2030692238 date "2012-11-26" @default.
• W2030692238 modified "2023-10-11" @default.
• W2030692238 title "Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS" @default.
• W2030692238 cites W1963778872 @default.
• W2030692238 cites W1975663082 @default.
• W2030692238 cites W1978748451 @default.
• W2030692238 cites W1990615139 @default.
• W2030692238 cites W1992743196 @default.
• W2030692238 cites W1996061504 @default.
• W2030692238 cites W2007469901 @default.
• W2030692238 cites W2008793028 @default.
• W2030692238 cites W2011796931 @default.
• W2030692238 cites W2014478761 @default.
• W2030692238 cites W2016411536 @default.
• W2030692238 cites W2018207514 @default.
• W2030692238 cites W2031394441 @default.
• W2030692238 cites W2065333202 @default.
• W2030692238 cites W2065631454 @default.
• W2030692238 cites W2070132182 @default.
• W2030692238 cites W2086972154 @default.
• W2030692238 cites W2101624429 @default.
• W2030692238 cites W2101640748 @default.
• W2030692238 cites W2104887197 @default.
• W2030692238 cites W2105273832 @default.
• W2030692238 cites W2124438200 @default.
• W2030692238 cites W2125170576 @default.
• W2030692238 cites W2125604001 @default.
• W2030692238 cites W2127934565 @default.
• W2030692238 cites W2129319296 @default.
• W2030692238 cites W2130655121 @default.
• W2030692238 cites W2131801155 @default.
• W2030692238 cites W2134377628 @default.
• W2030692238 cites W2138167941 @default.
• W2030692238 cites W2143701639 @default.
• W2030692238 cites W2144081223 @default.
• W2030692238 cites W2151260604 @default.
• W2030692238 cites W2157752040 @default.
• W2030692238 cites W2163341755 @default.
• W2030692238 cites W2172063653 @default.
• W2030692238 cites W2180229411 @default.
• W2030692238 cites W2394550688 @default.
• W2030692238 cites W2482593257 @default.
• W2030692238 cites W2506101630 @default.
• W2030692238 cites W4234317413 @default.
• W2030692238 doi "https://doi.org/10.1073/pnas.1209253109" @default.
• W2030692238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3529070" @default.
• W2030692238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23184990" @default.
• W2030692238 hasPublicationYear "2012" @default.
• W2030692238 type Work @default.
• W2030692238 sameAs 2030692238 @default.
• W2030692238 citedByCount "34" @default.
• W2030692238 countsByYear W20306922382013 @default.
• W2030692238 countsByYear W20306922382014 @default.
• W2030692238 countsByYear W20306922382015 @default.
• W2030692238 countsByYear W20306922382016 @default.
• W2030692238 countsByYear W20306922382017 @default.
• W2030692238 countsByYear W20306922382018 @default.
• W2030692238 countsByYear W20306922382019 @default.
• W2030692238 countsByYear W20306922382020 @default.
• W2030692238 countsByYear W20306922382022 @default.
• W2030692238 crossrefType "journal-article" @default.
• W2030692238 hasAuthorship W2030692238A5019622792 @default.
• W2030692238 hasAuthorship W2030692238A5027494787 @default.
• W2030692238 hasAuthorship W2030692238A5040792982 @default.
• W2030692238 hasAuthorship W2030692238A5044809005 @default.
• W2030692238 hasAuthorship W2030692238A5050261718 @default.
• W2030692238 hasAuthorship W2030692238A5058650693 @default.
• W2030692238 hasAuthorship W2030692238A5060473928 @default.
• W2030692238 hasAuthorship W2030692238A5074839838 @default.
• W2030692238 hasBestOaLocation W20306922381 @default.
• W2030692238 hasConcept C104317684 @default.
• W2030692238 hasConcept C136449434 @default.
• W2030692238 hasConcept C144464004 @default.
• W2030692238 hasConcept C159654299 @default.
• W2030692238 hasConcept C170493617 @default.
• W2030692238 hasConcept C203014093 @default.
• W2030692238 hasConcept C2776709828 @default.
• W2030692238 hasConcept C2778754761 @default.
• W2030692238 hasConcept C547475151 @default.
• W2030692238 hasConcept C55493867 @default.
• W2030692238 hasConcept C86803240 @default.
• W2030692238 hasConcept C8891405 @default.
• W2030692238 hasConcept C95444343 @default.
• W2030692238 hasConceptScore W2030692238C104317684 @default.
• W2030692238 hasConceptScore W2030692238C136449434 @default.
• W2030692238 hasConceptScore W2030692238C144464004 @default.
• W2030692238 hasConceptScore W2030692238C159654299 @default.
• W2030692238 hasConceptScore W2030692238C170493617 @default.

• next