FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030696232> ?p ?o ?g. }

• W2030696232 endingPage "1457" @default.
• W2030696232 startingPage "1453" @default.
• W2030696232 abstract "We hypothesized that correction of insulin deficiency by pulsatile intravenous insulin infusion in type 1 diabetes mellitus patients with nephropathy preserves renal function by mechanisms involving cardiac autonomic function, cardiac mass, or efficiency, or by hemostatic mechanisms. The control group (8 patients) received subcutaneous insulin (3-4 injections per day). The intravenous infusion group (10 patients) received three 1-hour courses of pulsed intravenous insulin infusion on a single day per week in addition to subcutaneous insulin. Laboratory measurements included 2-dimensional Doppler echocardiography, 24-hour ambulatory monitoring with heart rate variation analysis, platelet aggregation and adhesion, plasma fibrinogen, factor VII, von Willebrand factor, fibrinolytic activity, plasminogen activator inhibitor, and viscosity measured at baseline and 12 months. Blood pressure control was maintained preferentially with angiotensin-converting enzyme inhibitors. Ratio of carbon dioxide production to oxygen utilization was measured with each infusion and showed rapid increase from 0.8 to 0.9 (P = .005) at weekly treatments through 12 months. We observed an annualized decrease in creatinine clearance of 9.6 mL/min for controls vs 3.0 mL/min for infusion patients. Annualized fall in blood hemoglobin was 1.9 vs 0.8 g/dL, respectively (P = .013). There were no differences between the control and infusion group with respect to glycohemoglobin, advanced glycated end products, cholesterol, or triglycerides. No differences between the study groups for hemodynamic or hemostatic factors were evident. Blood pressures were not significantly different at baseline or 12 months. We conclude that although preservation of renal function with attenuation of loss of blood hemoglobin during 12 months of intravenous insulin infusion was associated with improvement in the efficiency of fuel oxidation as measured by respiratory quotient, this occurred without differences in metabolic/hemostatic factors, cardiac autonomic function, cardiac wall, or chamber size. Our hypothesis that preservation of renal function in type 1 diabetes mellitus patients with proteinuria by weekly pulsed insulin infusion involves mechanisms from the autonomic nervous system, cardiac size, and function, or elements of hemostasis was not confirmed." @default.
• W2030696232 created "2016-06-24" @default.
• W2030696232 creator A5007709659 @default.
• W2030696232 creator A5014110930 @default.
• W2030696232 creator A5031689253 @default.
• W2030696232 creator A5041758416 @default.
• W2030696232 creator A5067110312 @default.
• W2030696232 creator A5075668584 @default.
• W2030696232 date "2007-11-01" @default.
• W2030696232 modified "2023-10-16" @default.
• W2030696232 title "A pilot study to test the effect of pulsatile insulin infusion on cardiovascular mechanisms that might contribute to attenuation of renal compromise in type 1 diabetes mellitus patients with proteinuria" @default.
• W2030696232 cites W1971756463 @default.
• W2030696232 cites W1981346654 @default.
• W2030696232 cites W1982558842 @default.
• W2030696232 cites W1998986488 @default.
• W2030696232 cites W2006919788 @default.
• W2030696232 cites W2018196775 @default.
• W2030696232 cites W2036686750 @default.
• W2030696232 cites W2037724297 @default.
• W2030696232 cites W2047088101 @default.
• W2030696232 cites W2053107240 @default.
• W2030696232 cites W2057595956 @default.
• W2030696232 cites W2058709097 @default.
• W2030696232 cites W2062408616 @default.
• W2030696232 cites W2067983165 @default.
• W2030696232 cites W2072372646 @default.
• W2030696232 cites W2076886097 @default.
• W2030696232 cites W2078641298 @default.
• W2030696232 cites W2119514827 @default.
• W2030696232 cites W2130892097 @default.
• W2030696232 cites W2148440654 @default.
• W2030696232 cites W2162994762 @default.
• W2030696232 cites W2414275950 @default.
• W2030696232 doi "https://doi.org/10.1016/j.metabol.2007.05.016" @default.
• W2030696232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17950093" @default.
• W2030696232 hasPublicationYear "2007" @default.
• W2030696232 type Work @default.
• W2030696232 sameAs 2030696232 @default.
• W2030696232 citedByCount "8" @default.
• W2030696232 countsByYear W20306962322018 @default.
• W2030696232 countsByYear W20306962322020 @default.
• W2030696232 crossrefType "journal-article" @default.
• W2030696232 hasAuthorship W2030696232A5007709659 @default.
• W2030696232 hasAuthorship W2030696232A5014110930 @default.
• W2030696232 hasAuthorship W2030696232A5031689253 @default.
• W2030696232 hasAuthorship W2030696232A5041758416 @default.
• W2030696232 hasAuthorship W2030696232A5067110312 @default.
• W2030696232 hasAuthorship W2030696232A5075668584 @default.
• W2030696232 hasConcept C126322002 @default.
• W2030696232 hasConcept C134018914 @default.
• W2030696232 hasConcept C159641895 @default.
• W2030696232 hasConcept C164705383 @default.
• W2030696232 hasConcept C2777180221 @default.
• W2030696232 hasConcept C2777538456 @default.
• W2030696232 hasConcept C2779306644 @default.
• W2030696232 hasConcept C555293320 @default.
• W2030696232 hasConcept C71924100 @default.
• W2030696232 hasConceptScore W2030696232C126322002 @default.
• W2030696232 hasConceptScore W2030696232C134018914 @default.
• W2030696232 hasConceptScore W2030696232C159641895 @default.
• W2030696232 hasConceptScore W2030696232C164705383 @default.
• W2030696232 hasConceptScore W2030696232C2777180221 @default.
• W2030696232 hasConceptScore W2030696232C2777538456 @default.
• W2030696232 hasConceptScore W2030696232C2779306644 @default.
• W2030696232 hasConceptScore W2030696232C555293320 @default.
• W2030696232 hasConceptScore W2030696232C71924100 @default.
• W2030696232 hasIssue "11" @default.
• W2030696232 hasLocation W20306962321 @default.
• W2030696232 hasLocation W20306962322 @default.
• W2030696232 hasOpenAccess W2030696232 @default.
• W2030696232 hasPrimaryLocation W20306962321 @default.
• W2030696232 hasRelatedWork W1983641721 @default.
• W2030696232 hasRelatedWork W1995945960 @default.
• W2030696232 hasRelatedWork W2008378339 @default.
• W2030696232 hasRelatedWork W2026226896 @default.
• W2030696232 hasRelatedWork W2041678535 @default.
• W2030696232 hasRelatedWork W2066345847 @default.
• W2030696232 hasRelatedWork W2089387278 @default.
• W2030696232 hasRelatedWork W2095179743 @default.
• W2030696232 hasRelatedWork W2124070488 @default.
• W2030696232 hasRelatedWork W2130904138 @default.
• W2030696232 hasVolume "56" @default.
• W2030696232 isParatext "false" @default.
• W2030696232 isRetracted "false" @default.
• W2030696232 magId "2030696232" @default.
• W2030696232 workType "article" @default.