Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030698968> ?p ?o ?g. }
- W2030698968 endingPage "e38627" @default.
- W2030698968 startingPage "e38627" @default.
- W2030698968 abstract "l-Tetrahydropalmatine (l-THP) is an active ingredients of Corydalis yanhusuo W.T. Wang, which protects against acute global cerebral ischaemia-reperfusion injury. In this study, we show that l-THP is cardioprotective in myocardial ischaemia-reperfusion injury and examined the mechanism. Rats were treated with l-THP (0, 10, 20, 40 mg/kg b.w.) for 20 min before occlusion of the left anterior descending coronary artery and subjected to myocardial ischaemia-reperfusion (30 min/6 h). Compared with vehicle-treated animals, the infarct area/risk area (IA/RA) of l-THP (20, 40 mg/kg b.w.) treated rats was reduced, whilst l-THP (10 mg/kg b.w.) had no significant effect. Cardiac function was improved in l-THP-treated rats whilst plasma creatine kinase activity declined. Following treatment with l-THP (20 mg/kg b.w.), subunit of phosphatidylinositol 3-kinase p85, serine473 phosphorylation of Akt and serine1177 phosphorylation of endothelial NO synthase (eNOS) increased in myocardium, whilst expression of inducible NO synthase (iNOS) decreased. However, the expression of HIF-1α and VEGF were increased in I30 minR6 h, but decreased to normal level in I30 minR24 h, while treatment with l-THP (20 mg/kg b.w.) enhanced the levels of these two genes in I30 minR24 h. Production of NO in myocardium and plasma, activity of myeloperoxidase (MPO) in plasma and the expression of tumour necrosis factor-α (TNF-α) in myocardium were decreased by l-THP. TUNEL assay revealed that l-THP (20 mg/kg b.w.) reduced apoptosis in myocardium. Thus, we show that l-THP activates the PI3K/Akt/eNOS/NO pathway and increases expression of HIF-1α and VEGF, whilst depressing iNOS-derived NO production in myocardium. This effect may decrease the accumulation of inflammatory factors, including TNF-α and MPO, and lessen the extent of apoptosis, therefore contributing to the cardioprotective effects of l-THP in myocardial ischaemia-reperfusion injury." @default.
- W2030698968 created "2016-06-24" @default.
- W2030698968 creator A5002112806 @default.
- W2030698968 creator A5011806473 @default.
- W2030698968 creator A5012061915 @default.
- W2030698968 creator A5014708668 @default.
- W2030698968 creator A5025618652 @default.
- W2030698968 creator A5029885579 @default.
- W2030698968 creator A5037426639 @default.
- W2030698968 creator A5045722303 @default.
- W2030698968 creator A5046842321 @default.
- W2030698968 creator A5078949281 @default.
- W2030698968 creator A5081461782 @default.
- W2030698968 creator A5090381708 @default.
- W2030698968 date "2012-06-08" @default.
- W2030698968 modified "2023-09-26" @default.
- W2030698968 title "l-Tetrahydropalmatine, an Active Component of Corydalis yanhusuo W.T. Wang, Protects against Myocardial Ischaemia-Reperfusion Injury in Rats" @default.
- W2030698968 cites W1592450899 @default.
- W2030698968 cites W1607892649 @default.
- W2030698968 cites W1678800844 @default.
- W2030698968 cites W1886833444 @default.
- W2030698968 cites W1966281230 @default.
- W2030698968 cites W1969789448 @default.
- W2030698968 cites W1973470186 @default.
- W2030698968 cites W1983588728 @default.
- W2030698968 cites W1986378496 @default.
- W2030698968 cites W1990767395 @default.
- W2030698968 cites W1990792990 @default.
- W2030698968 cites W1995670762 @default.
- W2030698968 cites W1997457976 @default.
- W2030698968 cites W2001116487 @default.
- W2030698968 cites W2002567824 @default.
- W2030698968 cites W2006705030 @default.
- W2030698968 cites W2010267145 @default.
- W2030698968 cites W2022131685 @default.
- W2030698968 cites W2029491963 @default.
- W2030698968 cites W2033170367 @default.
- W2030698968 cites W2035168958 @default.
- W2030698968 cites W2039601697 @default.
- W2030698968 cites W2041492515 @default.
- W2030698968 cites W2046440184 @default.
- W2030698968 cites W2066457518 @default.
- W2030698968 cites W2067032425 @default.
- W2030698968 cites W2067806306 @default.
- W2030698968 cites W2075652728 @default.
- W2030698968 cites W2080725690 @default.
- W2030698968 cites W2082725460 @default.
- W2030698968 cites W2086251702 @default.
- W2030698968 cites W2097744068 @default.
- W2030698968 cites W2102883475 @default.
- W2030698968 cites W2109321136 @default.
- W2030698968 cites W2117574147 @default.
- W2030698968 cites W2122386753 @default.
- W2030698968 cites W2123417215 @default.
- W2030698968 cites W2131868847 @default.
- W2030698968 cites W2151673904 @default.
- W2030698968 cites W2154292087 @default.
- W2030698968 cites W2155115959 @default.
- W2030698968 cites W2157942480 @default.
- W2030698968 cites W2158878115 @default.
- W2030698968 cites W2167432569 @default.
- W2030698968 cites W2237719732 @default.
- W2030698968 doi "https://doi.org/10.1371/journal.pone.0038627" @default.
- W2030698968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3371051" @default.
- W2030698968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22715398" @default.
- W2030698968 hasPublicationYear "2012" @default.
- W2030698968 type Work @default.
- W2030698968 sameAs 2030698968 @default.
- W2030698968 citedByCount "46" @default.
- W2030698968 countsByYear W20306989682013 @default.
- W2030698968 countsByYear W20306989682014 @default.
- W2030698968 countsByYear W20306989682015 @default.
- W2030698968 countsByYear W20306989682016 @default.
- W2030698968 countsByYear W20306989682017 @default.
- W2030698968 countsByYear W20306989682018 @default.
- W2030698968 countsByYear W20306989682019 @default.
- W2030698968 countsByYear W20306989682020 @default.
- W2030698968 countsByYear W20306989682021 @default.
- W2030698968 countsByYear W20306989682022 @default.
- W2030698968 countsByYear W20306989682023 @default.
- W2030698968 crossrefType "journal-article" @default.
- W2030698968 hasAuthorship W2030698968A5002112806 @default.
- W2030698968 hasAuthorship W2030698968A5011806473 @default.
- W2030698968 hasAuthorship W2030698968A5012061915 @default.
- W2030698968 hasAuthorship W2030698968A5014708668 @default.
- W2030698968 hasAuthorship W2030698968A5025618652 @default.
- W2030698968 hasAuthorship W2030698968A5029885579 @default.
- W2030698968 hasAuthorship W2030698968A5037426639 @default.
- W2030698968 hasAuthorship W2030698968A5045722303 @default.
- W2030698968 hasAuthorship W2030698968A5046842321 @default.
- W2030698968 hasAuthorship W2030698968A5078949281 @default.
- W2030698968 hasAuthorship W2030698968A5081461782 @default.
- W2030698968 hasAuthorship W2030698968A5090381708 @default.
- W2030698968 hasBestOaLocation W20306989681 @default.
- W2030698968 hasConcept C126322002 @default.
- W2030698968 hasConcept C134018914 @default.
- W2030698968 hasConcept C185592680 @default.
- W2030698968 hasConcept C196795494 @default.