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- W2030723550 abstract "The structural integrity of cerebral vessels is compromised during ageing. Abnormal amyloid (Aβ) deposition in the vasculature can accelerate age-related pathologies. The cerebrovascular response associated with ageing and microvascular Aβ deposition was defined using quantitative label-free shotgun proteomic analysis. Over 650 proteins were quantified in vessel-enriched fractions from the brains of 3 and 9 month-old wild-type (WT) and Tg-SwDI mice. Sixty-five proteins were significantly increased in older WT animals and included several basement membrane proteins (nidogen-1, basement membrane-specific heparan sulfate proteoglycan core protein, laminin subunit gamma-1 precursor and collagen alpha-2(IV) chain preproprotein). Twenty-four proteins were increased and twenty-one decreased in older Tg-SwDI mice. Of these, increases in Apolipoprotein E (APOE) and high temperature requirement serine protease-1 (HTRA1) and decreases in spliceosome and RNA-binding proteins were the most prominent. Only six shared proteins were altered in both 9-month old WT and Tg-SwDI animals. The age-related proteomic response in the cerebrovasculature was distinctly different in the presence of microvascular Aβ deposition. Proteins found differentially expressed within the WT and Tg-SwDI animals give greater insight to the mechanisms behind age-related cerebrovascular dysfunction and pathologies and may provide novel therapeutic targets." @default.
- W2030723550 created "2016-06-24" @default.
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- W2030723550 date "2014-02-26" @default.
- W2030723550 modified "2023-10-03" @default.
- W2030723550 title "Impact of Age on the Cerebrovascular Proteomes of Wild-Type and Tg-SwDI Mice" @default.
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- W2030723550 doi "https://doi.org/10.1371/journal.pone.0089970" @default.
- W2030723550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3935958" @default.
- W2030723550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24587158" @default.
- W2030723550 hasPublicationYear "2014" @default.
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