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- W2030730591 abstract "The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina." @default.
- W2030730591 created "2016-06-24" @default.
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- W2030730591 date "2014-04-01" @default.
- W2030730591 modified "2023-09-24" @default.
- W2030730591 title "Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line" @default.
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- W2030730591 doi "https://doi.org/10.1016/j.bbrc.2014.02.135" @default.
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