Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030734810> ?p ?o ?g. }
- W2030734810 endingPage "1198" @default.
- W2030734810 startingPage "1187" @default.
- W2030734810 abstract "Disparities in cocaine-induced neurochemical and metabolic responses between human beings and rodents motivate the use of non-human primates (NHP) to model consequences of repeated cocaine exposure in human subjects. To characterize the functional response to cocaine infusion in NHP brain, we employed contrast-enhanced fMRI during both non-contingent injection of drug and self-administration of cocaine in the magnet. Cocaine robustly decreased cerebral blood volume (CBV) throughout basal ganglia and motor/pre-motor cortex and produced subtle functional inhibition of prefrontal cortex. No brain regions exhibited significant elevation of CBV in response to cocaine challenge. Theses effects in NHP brain are opposite in sign to the cocaine-induced fMRI response in rats, but consistent with previous measurements in NHP based on glucose metabolism. Because the striatal ratio of D2 to D1 receptors is larger in human beings and NHP than rats, we hypothesize that the inhibitory effects of D2 receptor binding dominate the functional response in primates, whereas excitatory D1 receptor stimulation predominates in the rat. If the NHP accurately models the human response to cocaine, downregulation of D2 receptors in human cocaine-abusing populations can be expected to blunt cocaine-induced functional responses, contributing to the weak and variable fMRI responses reported in human basal ganglia following cocaine infusion." @default.
- W2030734810 created "2016-06-24" @default.
- W2030734810 creator A5004268054 @default.
- W2030734810 creator A5010268909 @default.
- W2030734810 creator A5019086139 @default.
- W2030734810 creator A5027397904 @default.
- W2030734810 creator A5075565019 @default.
- W2030734810 creator A5077577798 @default.
- W2030734810 date "2011-02-09" @default.
- W2030734810 modified "2023-10-18" @default.
- W2030734810 title "fMRI of Cocaine Self-Administration in Macaques Reveals Functional Inhibition of Basal Ganglia" @default.
- W2030734810 cites W133522629 @default.
- W2030734810 cites W1506870724 @default.
- W2030734810 cites W1536218996 @default.
- W2030734810 cites W1785721624 @default.
- W2030734810 cites W1958770241 @default.
- W2030734810 cites W1963530831 @default.
- W2030734810 cites W1965939967 @default.
- W2030734810 cites W1966405444 @default.
- W2030734810 cites W1971432878 @default.
- W2030734810 cites W1973973602 @default.
- W2030734810 cites W1975870239 @default.
- W2030734810 cites W1975938737 @default.
- W2030734810 cites W1977453267 @default.
- W2030734810 cites W1977646891 @default.
- W2030734810 cites W1979792701 @default.
- W2030734810 cites W1982047175 @default.
- W2030734810 cites W1982495462 @default.
- W2030734810 cites W1982896359 @default.
- W2030734810 cites W1984107526 @default.
- W2030734810 cites W1986099115 @default.
- W2030734810 cites W1986312314 @default.
- W2030734810 cites W1987599891 @default.
- W2030734810 cites W1995793779 @default.
- W2030734810 cites W1995796138 @default.
- W2030734810 cites W1996352444 @default.
- W2030734810 cites W1997829966 @default.
- W2030734810 cites W2001905067 @default.
- W2030734810 cites W2004768679 @default.
- W2030734810 cites W2005008592 @default.
- W2030734810 cites W2005698271 @default.
- W2030734810 cites W2009243814 @default.
- W2030734810 cites W2009608813 @default.
- W2030734810 cites W2011542286 @default.
- W2030734810 cites W2018345883 @default.
- W2030734810 cites W2030871689 @default.
- W2030734810 cites W2030998971 @default.
- W2030734810 cites W2031055573 @default.
- W2030734810 cites W2032188840 @default.
- W2030734810 cites W2034964468 @default.
- W2030734810 cites W2036658811 @default.
- W2030734810 cites W2037209558 @default.
- W2030734810 cites W2045434168 @default.
- W2030734810 cites W2052280773 @default.
- W2030734810 cites W2054388727 @default.
- W2030734810 cites W2054737462 @default.
- W2030734810 cites W2056321231 @default.
- W2030734810 cites W2058103878 @default.
- W2030734810 cites W2058284686 @default.
- W2030734810 cites W2060816711 @default.
- W2030734810 cites W2062608310 @default.
- W2030734810 cites W2062769941 @default.
- W2030734810 cites W2065218488 @default.
- W2030734810 cites W2069453047 @default.
- W2030734810 cites W2076702034 @default.
- W2030734810 cites W2077049571 @default.
- W2030734810 cites W2077801777 @default.
- W2030734810 cites W2079048674 @default.
- W2030734810 cites W2085749739 @default.
- W2030734810 cites W2090481799 @default.
- W2030734810 cites W2096610186 @default.
- W2030734810 cites W2097845013 @default.
- W2030734810 cites W2101008456 @default.
- W2030734810 cites W2105109101 @default.
- W2030734810 cites W2105612509 @default.
- W2030734810 cites W2106287416 @default.
- W2030734810 cites W2110344324 @default.
- W2030734810 cites W2111388536 @default.
- W2030734810 cites W2116572093 @default.
- W2030734810 cites W2118569540 @default.
- W2030734810 cites W2122284725 @default.
- W2030734810 cites W2122620193 @default.
- W2030734810 cites W2123766280 @default.
- W2030734810 cites W2125364966 @default.
- W2030734810 cites W2126349398 @default.
- W2030734810 cites W2126884841 @default.
- W2030734810 cites W2131375848 @default.
- W2030734810 cites W2139989864 @default.
- W2030734810 cites W2142461473 @default.
- W2030734810 cites W2145737112 @default.
- W2030734810 cites W2146373284 @default.
- W2030734810 cites W2149044583 @default.
- W2030734810 cites W2160349805 @default.
- W2030734810 cites W2167264579 @default.
- W2030734810 cites W2170378957 @default.
- W2030734810 cites W2170920257 @default.
- W2030734810 doi "https://doi.org/10.1038/npp.2011.1" @default.
- W2030734810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079280" @default.