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• W2030747477 abstract "Deficits in self monitoring are a core feature of cognitive dysfunction in schizophrenia, and may be the basis for disturbances of self and lack of insight, ultimately impacting social functioning. However, the functional and structural neural correlates of such deficits in self monitoring are not well understood. We investigated this issue using measurements of neurophysiological and structural brain indices, i.e., error-related and correct-response negativity (ERN & CRN) of event-related potentials, and gray matter volume of the anterior cingulate cortex (ACC), and tested whether the association between these indices is altered in patients with schizophrenia. Participants consisted of 18 male patients with chronic schizophrenia and 18 healthy male controls. The 2 groups did not differ in ERN amplitude. In contrast, schizophrenia patients showed significantly larger CRN amplitudes than did healthy subjects. Although the 2 groups did not significantly differ in gray matter volume of the ACC subregions, a significant negative correlation was found between ERN amplitudes at the frontocentral electrodes and absolute gray matter volumes of the left cognitive region of ACC only in healthy controls. These results suggest a disruption of function–structure coupling of the brain regions sub-serving self monitoring in schizophrenia." @default.
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• W2030747477 date "2013-05-01" @default.
• W2030747477 modified "2023-10-16" @default.
• W2030747477 title "Disruption of function–structure coupling in brain regions sub-serving self monitoring in schizophrenia" @default.
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• W2030747477 doi "https://doi.org/10.1016/j.schres.2013.02.028" @default.
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