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- W203074940 abstract "Objective To investigate the expression of COX 2 proteins in gastric mucosal lesions and to assess the relationship between expression of COX 2 and type,pathologic stage,differentiation,or lymph node metastasis in gastric cancer and the relationship between expression of COX 2 and H.pylori infection in gastric mucosal lesions.Methods 30 patients with gastric carcinoma underwent surgical resection.Samples were taken from tumor site and paracancerous tissues,and ABC immunohistochemical staining was used to detect the expression of COX 2 proteins.H.pylori was determined by rapid urea test combined with pathological stating/ 14 C urea breath test.Results The positive rate and staining intensity of mutant COX 2 gene expression in gastric cancer were significantly higher than those in paracancerous tissues ( P 0 01, P 0 001);There was significant correlation between COX 2 and pathologic stage or lymph node metastasis type of gastric carcinoma(p all0 05);No correlation between COX 2 expression and type or grade of differentiation(p all0 05).COX 2 expression of IM or DYS with H.pylori positive was significantly higher than that with H.pylori negative ( P 0 05).Conclusion Overexpression of COX 2 was found in a large proportion of gastric cancer tissues compared with matched non cancerous tissues and was significantly associated with advanced tumor stage and lymph node metastasis.Overexpression of COX 2 plays an importamt role in tumor progression of gastric cancer.COX 2 may also play a role in the early development/progress of gastric carcinoma and are associated with H.pylori infection." @default.
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- W203074940 date "2002-01-01" @default.
- W203074940 modified "2023-09-22" @default.
- W203074940 title "The expression of COX-2 proteins in gastric mucosal lesions" @default.
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