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• W2030752472 abstract "Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with no proven effective medical therapy. Ursodeoxycholic acid (UDCA) was proposed as a potential treatment for this disorder. However, several randomised controlled trials reported conflicting results regarding the usefulness of UDCA. The aim of this meta-analysis and systematic review is to investigate the efficacy of UDCA in PSC. Literature review was performed to include randomised controlled trials and non-randomised studies comparing UDCA to a placebo in PSC. The included controlled trials were assigned a quality score. Random effects model was used. Outcomes were measured with Weight Mean Difference, Risk Ratio or Risk Difference. Heterogeneity was measured by I2 measure of inconsistency. Seven RCTs satisfied the inclusion criteria with a total number of 553 patients. Low dose UDCA was used in 4 studies, high dose UDCA (17–30 mg/kg) was used in three studies. UDCA did not decrease the risk of mortality compared to placebo (RR = 1.04, 95% CI 0.46–2.35) or the need for liver transplant (RR = 1.22, 95% CI 0.7–2.12). UDCA also had no effect on the clinical symptoms. Liver Function Tests (LFTs) were significantly improved in the UDCA treated patients. UDCA did not decrease the incidence of cholangiocarcinoma. UDCA had no beneficial effect on the patients’ survival, liver histology, prevention of cholangiocarcinoma, or improvement of clinical symptoms. High dose UDCA was associated with increased mortality in one of the large randomised trial included in this analysis." @default.
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• W2030752472 date "2012-09-01" @default.
• W2030752472 modified "2023-10-16" @default.
• W2030752472 title "Urosdeoxycholic acid in primary sclerosing cholangitis: A meta-analysis and systematic review" @default.
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• W2030752472 doi "https://doi.org/10.1016/j.ajg.2012.06.011" @default.
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