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- W2030754297 abstract "Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleosides for the treatment of AT. Promising hits were identified with excellent in vitro activity across all important animal trypanosome species. Compound 7, an inosine analogue, and our previously described lead compound, 3′-deoxytubercidin (8), showed broad spectrum anti-AT activity, metabolic stability in the target host species and absence of toxicity, but with variable efficacy ranging from limited activity to full cure in mouse models of Trypanosoma congolense and T. vivax infection. Several compounds show promise against T. evansi (surra) and T. equiperdum (dourine). Given the preferred target product profile for a broad-spectrum compound against AT, this study emphasizes the need to include T. vivax in the screening cascade given its divergent susceptibility profile and provides a basis for lead optimization towards such broad spectrum anti-AT compound." @default.
- W2030754297 created "2016-06-24" @default.
- W2030754297 creator A5002906045 @default.
- W2030754297 creator A5069558437 @default.
- W2030754297 date "1981-01-01" @default.
- W2030754297 modified "2023-10-14" @default.
- W2030754297 title "Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the eastern hemisphere" @default.
- W2030754297 cites W149542973 @default.
- W2030754297 cites W1517990838 @default.
- W2030754297 cites W1531974714 @default.
- W2030754297 cites W1537286564 @default.
- W2030754297 cites W1587220145 @default.
- W2030754297 cites W159985551 @default.
- W2030754297 cites W1762107533 @default.
- W2030754297 cites W1771298272 @default.
- W2030754297 cites W185783770 @default.
- W2030754297 cites W1901563507 @default.
- W2030754297 cites W1965264293 @default.
- W2030754297 cites W1966250171 @default.
- W2030754297 cites W1967152207 @default.
- W2030754297 cites W1968260544 @default.
- W2030754297 cites W1968645285 @default.
- W2030754297 cites W1970400274 @default.
- W2030754297 cites W1970978398 @default.
- W2030754297 cites W1971246110 @default.
- W2030754297 cites W1971354830 @default.
- W2030754297 cites W1972220947 @default.
- W2030754297 cites W1975515894 @default.
- W2030754297 cites W1976424553 @default.
- W2030754297 cites W1978977936 @default.
- W2030754297 cites W1982178668 @default.
- W2030754297 cites W1983955673 @default.
- W2030754297 cites W1990785406 @default.
- W2030754297 cites W1991311867 @default.
- W2030754297 cites W1992408373 @default.
- W2030754297 cites W1992760440 @default.
- W2030754297 cites W1993493628 @default.
- W2030754297 cites W1994625980 @default.
- W2030754297 cites W1996211962 @default.
- W2030754297 cites W1996404177 @default.
- W2030754297 cites W1998029623 @default.
- W2030754297 cites W2002691542 @default.
- W2030754297 cites W2004326833 @default.
- W2030754297 cites W2005098865 @default.
- W2030754297 cites W2005667122 @default.
- W2030754297 cites W2010052870 @default.
- W2030754297 cites W2010869083 @default.
- W2030754297 cites W2011575084 @default.
- W2030754297 cites W2013777656 @default.
- W2030754297 cites W2014514025 @default.
- W2030754297 cites W2014869207 @default.
- W2030754297 cites W2016589317 @default.
- W2030754297 cites W2017207869 @default.
- W2030754297 cites W2017547476 @default.
- W2030754297 cites W2018189242 @default.
- W2030754297 cites W2018438408 @default.
- W2030754297 cites W2019574523 @default.
- W2030754297 cites W2019770096 @default.
- W2030754297 cites W2020239963 @default.
- W2030754297 cites W2023308573 @default.
- W2030754297 cites W2024395547 @default.
- W2030754297 cites W2026689947 @default.
- W2030754297 cites W2026756047 @default.
- W2030754297 cites W2026903865 @default.
- W2030754297 cites W2027311152 @default.
- W2030754297 cites W2028791409 @default.
- W2030754297 cites W2034857067 @default.
- W2030754297 cites W2037583065 @default.
- W2030754297 cites W2039562899 @default.
- W2030754297 cites W2041007953 @default.
- W2030754297 cites W2042634108 @default.
- W2030754297 cites W2043000317 @default.
- W2030754297 cites W2045686470 @default.
- W2030754297 cites W2049090110 @default.
- W2030754297 cites W2050177290 @default.
- W2030754297 cites W2050265137 @default.
- W2030754297 cites W2051138639 @default.
- W2030754297 cites W2051535665 @default.
- W2030754297 cites W2052408687 @default.
- W2030754297 cites W2053357390 @default.
- W2030754297 cites W2053775329 @default.
- W2030754297 cites W2054591552 @default.
- W2030754297 cites W2059950712 @default.
- W2030754297 cites W2064488465 @default.
- W2030754297 cites W2065311862 @default.
- W2030754297 cites W2065452826 @default.
- W2030754297 cites W2067084379 @default.
- W2030754297 cites W2067331324 @default.
- W2030754297 cites W2068544923 @default.
- W2030754297 cites W2069254001 @default.
- W2030754297 cites W2073074202 @default.
- W2030754297 cites W2073687772 @default.
- W2030754297 cites W2077702690 @default.
- W2030754297 cites W2080974188 @default.
- W2030754297 cites W2084987097 @default.
- W2030754297 cites W2086297673 @default.
- W2030754297 cites W2090431421 @default.
- W2030754297 cites W2092003434 @default.