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• W2030755561 abstract "Multiple courses of Antenatal Corticosteroids for preterm birth Study (MACS) was an international multi-centered double-blind randomized controlled trial of single vs. multiple courses of antenatal corticosteroids (ACS). Infants exposed to ACS experienced similar composite morbidity and mortality as compared to placebo (12.9 % ACS vs. 12.5% placebo) OR 1.04 (CI 0.77-1.39 p=0.83). Infants in the ACS group were smaller. They weighed less (2216 g vs. 2330 g, p=0.0026), were shorter (44.5 cm vs. 45.4 cm, p=0.001) and had a smaller head circumference (31.1 cm vs. 31.7 cm, p=0.001) vs. placebo. The objective of these secondary analyses was to determine the effect of multiple courses of ACS on infant size, controlling for gestational age at birth and other confounders, and to determine if there was a dose response relationship between infant size and number of courses of ACS. All women (n=1858) and infants (n=2304) enrolled in MACS were included. The gestational age at birth was compared between randomized groups. Multiple linear regression analyses were undertaken to estimate differences (SE) in birth weight, length and head circumference, for the ACS vs. placebo groups, controlling for gestational age at birth and other confounders. Compared to placebo, infants exposed to ACS were born earlier (estimated difference [SE]: −0.43 weeks [0.17], p= 0.0098). Controlling for gestational age at birth and other known confounders, multiple courses of ACS were associated with a decrease in birth weight (-33.5 g [SE 16.7] p=0.045), length (-0.3 cm [SE 0.14] p=0.0187) and head circumference (-0.3 cm [SE 0.08] p=0.0003). Lastly, for each additional course of ACS, there was a trend towards an incremental decrease in birth weight, length and head circumference. Infants exposed to multiple courses of ACS were born earlier and were smaller. In addition, a dose response was noted between the increasing number of courses of ACS and a decrease in birth weight, length and head circumference. Therefore, administration of multiple courses of ACS, every 14 days, is not recommended." @default.
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• W2030755561 date "2012-01-01" @default.
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• W2030755561 title "498: Do antenatal corticosteroids reduce fetal growth or gestational age at birth? A secondary analysis from the multiple courses of antenatal corticosteroids for preterm birth study (MACS)" @default.
• W2030755561 doi "https://doi.org/10.1016/j.ajog.2011.10.516" @default.
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