FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030758070> ?p ?o ?g. }

• W2030758070 endingPage "e14258" @default.
• W2030758070 startingPage "e14258" @default.
• W2030758070 abstract "The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA) in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR) protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV) core protein. DDX3 physically binds viral RNA to form IPS-1-containing spots, that are visible by confocal microscopy. HCV polyU/UC induced IPS-1-mediated interferon (IFN)-beta promoter activation, which was augmented by co-transfected DDX3. DDX3 spots localized near the lipid droplets (LDs) where HCV particles were generated. Here, we report that HCV core protein interferes with DDX3-enhanced IPS-1 signaling in HEK293 cells and in hepatocyte Oc cells. Unlike the DEAD box helicases RIG-I and MDA5, DDX3 was constitutively expressed and colocalized with IPS-1 around mitochondria. In hepatocytes (O cells) with the HCV replicon, however, DDX3/IPS-1-enhanced IFN-beta-induction was largely abrogated even when DDX3 was co-expressed. DDX3 spots barely merged with IPS-1, and partly assembled in the HCV core protein located near the LD in O cells, though in some O cells IPS-1 was diminished or disseminated apart from mitochondria. Expression of DDX3 in replicon-negative or core-less replicon-positive cells failed to cause complex formation or LD association. HCV core protein and DDX3 partially colocalized only in replicon-expressing cells. Since the HCV core protein has been reported to promote HCV replication through binding to DDX3, the core protein appears to switch DDX3 from an IFN-inducing mode to an HCV-replication mode. The results enable us to conclude that HCV infection is promoted by modulating the dual function of DDX3." @default.
• W2030758070 created "2016-06-24" @default.
• W2030758070 creator A5012169699 @default.
• W2030758070 creator A5018553332 @default.
• W2030758070 creator A5026811152 @default.
• W2030758070 creator A5041139736 @default.
• W2030758070 creator A5043184323 @default.
• W2030758070 creator A5056230564 @default.
• W2030758070 creator A5071402791 @default.
• W2030758070 creator A5089756486 @default.
• W2030758070 creator A5089860635 @default.
• W2030758070 date "2010-12-08" @default.
• W2030758070 modified "2023-09-25" @default.
• W2030758070 title "Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction" @default.
• W2030758070 cites W1529133069 @default.
• W2030758070 cites W1667782349 @default.
• W2030758070 cites W1968178474 @default.
• W2030758070 cites W1978216180 @default.
• W2030758070 cites W1980321878 @default.
• W2030758070 cites W1987003850 @default.
• W2030758070 cites W1990521726 @default.
• W2030758070 cites W1993374643 @default.
• W2030758070 cites W1993457378 @default.
• W2030758070 cites W1993849863 @default.
• W2030758070 cites W2000703662 @default.
• W2030758070 cites W2013092102 @default.
• W2030758070 cites W2013601771 @default.
• W2030758070 cites W2018828712 @default.
• W2030758070 cites W2028575270 @default.
• W2030758070 cites W2032558535 @default.
• W2030758070 cites W2049115723 @default.
• W2030758070 cites W2051481258 @default.
• W2030758070 cites W2057967679 @default.
• W2030758070 cites W2066691052 @default.
• W2030758070 cites W2067806384 @default.
• W2030758070 cites W2068551986 @default.
• W2030758070 cites W2076294822 @default.
• W2030758070 cites W2078188527 @default.
• W2030758070 cites W2085795760 @default.
• W2030758070 cites W2087804239 @default.
• W2030758070 cites W2090457486 @default.
• W2030758070 cites W2092110803 @default.
• W2030758070 cites W2093579074 @default.
• W2030758070 cites W2096166831 @default.
• W2030758070 cites W2100665873 @default.
• W2030758070 cites W2103500013 @default.
• W2030758070 cites W2107513655 @default.
• W2030758070 cites W2118317431 @default.
• W2030758070 cites W2118926211 @default.
• W2030758070 cites W2119167328 @default.
• W2030758070 cites W2128009173 @default.
• W2030758070 cites W2129976921 @default.
• W2030758070 cites W2133929317 @default.
• W2030758070 cites W2136329789 @default.
• W2030758070 cites W2137303998 @default.
• W2030758070 cites W2141137217 @default.
• W2030758070 cites W2145783052 @default.
• W2030758070 cites W2154672212 @default.
• W2030758070 cites W2155908452 @default.
• W2030758070 cites W2165591553 @default.
• W2030758070 doi "https://doi.org/10.1371/journal.pone.0014258" @default.
• W2030758070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2999533" @default.
• W2030758070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21170385" @default.
• W2030758070 hasPublicationYear "2010" @default.
• W2030758070 type Work @default.
• W2030758070 sameAs 2030758070 @default.
• W2030758070 citedByCount "69" @default.
• W2030758070 countsByYear W20307580702012 @default.
• W2030758070 countsByYear W20307580702013 @default.
• W2030758070 countsByYear W20307580702014 @default.
• W2030758070 countsByYear W20307580702015 @default.
• W2030758070 countsByYear W20307580702016 @default.
• W2030758070 countsByYear W20307580702017 @default.
• W2030758070 countsByYear W20307580702018 @default.
• W2030758070 countsByYear W20307580702019 @default.
• W2030758070 countsByYear W20307580702020 @default.
• W2030758070 countsByYear W20307580702021 @default.
• W2030758070 countsByYear W20307580702022 @default.
• W2030758070 countsByYear W20307580702023 @default.
• W2030758070 crossrefType "journal-article" @default.
• W2030758070 hasAuthorship W2030758070A5012169699 @default.
• W2030758070 hasAuthorship W2030758070A5018553332 @default.
• W2030758070 hasAuthorship W2030758070A5026811152 @default.
• W2030758070 hasAuthorship W2030758070A5041139736 @default.
• W2030758070 hasAuthorship W2030758070A5043184323 @default.
• W2030758070 hasAuthorship W2030758070A5056230564 @default.
• W2030758070 hasAuthorship W2030758070A5071402791 @default.
• W2030758070 hasAuthorship W2030758070A5089756486 @default.
• W2030758070 hasAuthorship W2030758070A5089860635 @default.
• W2030758070 hasBestOaLocation W20307580701 @default.
• W2030758070 hasConcept C104317684 @default.
• W2030758070 hasConcept C153911025 @default.
• W2030758070 hasConcept C159047783 @default.
• W2030758070 hasConcept C161223559 @default.
• W2030758070 hasConcept C174510640 @default.
• W2030758070 hasConcept C18103114 @default.
• W2030758070 hasConcept C185592680 @default.
• W2030758070 hasConcept C22744801 @default.

• next