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• W2030759570 abstract "Copper catalyzed azide-alkyne cycloaddition (CuAAC) chemistry is reported for the construction of previously unknown 5-(1H-1,2,3-triazol-1-yl)-4,5'-bithiazoles from 2-bromo-1-(thiazol-5-yl)ethanones. These novel triazolobithiazoles are shown to have cystic fibrosis (CF) corrector activity and, compared to the benchmark bithiazole CF corrector corr-4a, improved logP values (4.5 vs 5.96)." @default.
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• W2030759570 date "2012-09-01" @default.
• W2030759570 modified "2023-10-11" @default.
• W2030759570 title "Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis" @default.
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• W2030759570 doi "https://doi.org/10.1016/j.bmc.2012.06.046" @default.
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