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- W2030761448 endingPage "1025" @default.
- W2030761448 startingPage "1011" @default.
- W2030761448 abstract "This review explores the hypothesis that regulation of nucleocytoplasmic shuttling is a means of driving differentiation, using spermatogenesis as a model. The transition from undifferentiated spermatogonial stem cell to terminally differentiated spermatozoon is, at its most basic, a change in the repertoire of expressed genes. To effect this, the complement of nuclear proteins, such as transcription factors and chromatin remodelling components must change. Current knowledge of the nuclear proteins and nucleocytoplasmic transport machinery relevant to spermatogenesis is consolidated in this review, and their functional linkages are highlighted not only as a means of regulating nuclear protein composition, but also as a key mechanism regulating gene transcription and hence cell fate. Through this, we hypothesize that male germ cell differentiation is mediated through regulation of nuclear transport machinery components, and thereby of the access of critical factors to the nucleus. The importance of nucleocytoplasmic trafficking to male germ cell differentiation is discussed, using the sex-determining factors Sry and SOX9, cell cycle regulators, CREM and cofactors and the Smads as specific examples, together with the roles in gametogenesis for particular nuclear transport factors in Caenorhabditis elegans and Drosophila." @default.
- W2030761448 created "2016-06-24" @default.
- W2030761448 creator A5004753497 @default.
- W2030761448 creator A5026603966 @default.
- W2030761448 creator A5070182251 @default.
- W2030761448 creator A5086376089 @default.
- W2030761448 date "2005-01-01" @default.
- W2030761448 modified "2023-09-23" @default.
- W2030761448 title "Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?" @default.
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