Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030763707> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2030763707 endingPage "223" @default.
- W2030763707 startingPage "220" @default.
- W2030763707 abstract "Multiple sclerosis (MS) is an autoimmune-mediated inflammatory and debilitating disease of the central nervous system. Several investigations have suggested that the mitochondrial DNA encoded subunits of complex I gene variations are involved in the progression of MS. In this study, we investigated the possible association between mitochondrial complex I gene variations and MS in a Filipino population.A total of 300 individuals were included in the present study, two-hundred patients with MS clinical symptoms, and one-hundred healthy subjects without MS clinical features. We amplified target genes of mtDNA using polymerase chain reaction technique (PCR), and sequenced these to evaluate mitochondrial complex I gene variations.We found nine variations (Nt 4216 T>C, Nt 5153 A>G, Nt 10142 C>T, Nt 11353 T>C, Nt 11935 T>C, Nt 12062 C>T, Nt 13042 G>A, Nt 13708 G>A and Nt 14179 G>A) in mtDNA-encoded complex I subunit genes. Our results showed that the prevalence of ND1, ND2, ND3, ND4 and ND5 gene variations was significantly higher in patients than in healthy controls (P<0.0001). Whereas, the frequency of Nt 14179 G>A variation in ND6 gene was significantly higher in the control group compared with the patients (P<0.0001).Taken together our data supports a strongly positive association between mitochondrial complex I gene variations and MS pathogenesis in a Filipino population." @default.
- W2030763707 created "2016-06-24" @default.
- W2030763707 creator A5002744614 @default.
- W2030763707 creator A5008926074 @default.
- W2030763707 creator A5013818654 @default.
- W2030763707 creator A5056479761 @default.
- W2030763707 creator A5076888775 @default.
- W2030763707 date "2014-10-01" @default.
- W2030763707 modified "2023-09-23" @default.
- W2030763707 title "Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis" @default.
- W2030763707 cites W1909184393 @default.
- W2030763707 cites W1964821857 @default.
- W2030763707 cites W1965942744 @default.
- W2030763707 cites W1966691625 @default.
- W2030763707 cites W1977963038 @default.
- W2030763707 cites W1996450150 @default.
- W2030763707 cites W1998583988 @default.
- W2030763707 cites W2015016389 @default.
- W2030763707 cites W2017267148 @default.
- W2030763707 cites W2026737235 @default.
- W2030763707 cites W2036337813 @default.
- W2030763707 cites W2057495929 @default.
- W2030763707 cites W2062858947 @default.
- W2030763707 cites W2065246627 @default.
- W2030763707 cites W2118855202 @default.
- W2030763707 cites W2130355701 @default.
- W2030763707 cites W2130497877 @default.
- W2030763707 cites W2132344128 @default.
- W2030763707 cites W2134286721 @default.
- W2030763707 cites W2156127065 @default.
- W2030763707 cites W2171638979 @default.
- W2030763707 cites W2354350348 @default.
- W2030763707 cites W4367165742 @default.
- W2030763707 doi "https://doi.org/10.1016/j.jns.2014.07.051" @default.
- W2030763707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25172194" @default.
- W2030763707 hasPublicationYear "2014" @default.
- W2030763707 type Work @default.
- W2030763707 sameAs 2030763707 @default.
- W2030763707 citedByCount "11" @default.
- W2030763707 countsByYear W20307637072016 @default.
- W2030763707 countsByYear W20307637072017 @default.
- W2030763707 countsByYear W20307637072018 @default.
- W2030763707 countsByYear W20307637072019 @default.
- W2030763707 countsByYear W20307637072020 @default.
- W2030763707 countsByYear W20307637072021 @default.
- W2030763707 countsByYear W20307637072022 @default.
- W2030763707 crossrefType "journal-article" @default.
- W2030763707 hasAuthorship W2030763707A5002744614 @default.
- W2030763707 hasAuthorship W2030763707A5008926074 @default.
- W2030763707 hasAuthorship W2030763707A5013818654 @default.
- W2030763707 hasAuthorship W2030763707A5056479761 @default.
- W2030763707 hasAuthorship W2030763707A5076888775 @default.
- W2030763707 hasConcept C104317684 @default.
- W2030763707 hasConcept C153911025 @default.
- W2030763707 hasConcept C203014093 @default.
- W2030763707 hasConcept C24586158 @default.
- W2030763707 hasConcept C2780640218 @default.
- W2030763707 hasConcept C2780942790 @default.
- W2030763707 hasConcept C2908647359 @default.
- W2030763707 hasConcept C49105822 @default.
- W2030763707 hasConcept C54355233 @default.
- W2030763707 hasConcept C71924100 @default.
- W2030763707 hasConcept C86803240 @default.
- W2030763707 hasConcept C99454951 @default.
- W2030763707 hasConceptScore W2030763707C104317684 @default.
- W2030763707 hasConceptScore W2030763707C153911025 @default.
- W2030763707 hasConceptScore W2030763707C203014093 @default.
- W2030763707 hasConceptScore W2030763707C24586158 @default.
- W2030763707 hasConceptScore W2030763707C2780640218 @default.
- W2030763707 hasConceptScore W2030763707C2780942790 @default.
- W2030763707 hasConceptScore W2030763707C2908647359 @default.
- W2030763707 hasConceptScore W2030763707C49105822 @default.
- W2030763707 hasConceptScore W2030763707C54355233 @default.
- W2030763707 hasConceptScore W2030763707C71924100 @default.
- W2030763707 hasConceptScore W2030763707C86803240 @default.
- W2030763707 hasConceptScore W2030763707C99454951 @default.
- W2030763707 hasIssue "1-2" @default.
- W2030763707 hasLocation W20307637071 @default.
- W2030763707 hasLocation W20307637072 @default.
- W2030763707 hasOpenAccess W2030763707 @default.
- W2030763707 hasPrimaryLocation W20307637071 @default.
- W2030763707 hasRelatedWork W1903480467 @default.
- W2030763707 hasRelatedWork W2013707927 @default.
- W2030763707 hasRelatedWork W2052710328 @default.
- W2030763707 hasRelatedWork W2055279078 @default.
- W2030763707 hasRelatedWork W2057053564 @default.
- W2030763707 hasRelatedWork W2067498190 @default.
- W2030763707 hasRelatedWork W2076407061 @default.
- W2030763707 hasRelatedWork W2095377562 @default.
- W2030763707 hasRelatedWork W2376017112 @default.
- W2030763707 hasRelatedWork W2387073411 @default.
- W2030763707 hasVolume "345" @default.
- W2030763707 isParatext "false" @default.
- W2030763707 isRetracted "false" @default.
- W2030763707 magId "2030763707" @default.
- W2030763707 workType "article" @default.