Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030772020> ?p ?o ?g. }
- W2030772020 endingPage "740" @default.
- W2030772020 startingPage "731" @default.
- W2030772020 abstract "Exogenous melatonin (MT) has significant neuroprotective roles in Alzheimer's and Parkinson's diseases. This study investigates the delivery MT to brain via nasal route as a polymeric gel suspension using central brain microdialysis in anesthetized rats.Micronized MT suspensions using polymers [carbopol, carboxymethyl cellulose (CMC)] and polyethylene glycol 400 (PEG400) were prepared and characterized for nasal administration. In vitro permeation of the formulations was measured across a three-dimensional tissue culture model EpiAirway(™). The central brain delivery into olfactory bulb of nasally administered MT gel suspensions was studied using brain microdialysis in male Wistar rats. The MT content of microdialysis samples was analyzed by high performance liquid chromatography (HPLC) using electrochemical detection. The nose-to-brain delivery of MT formulations was compared with intravenously administered MT solution.MT suspensions in carbopol and CMC vehicles have shown significantly higher permeability across Epiairway(™) as compared to control, PEG400 (P < 0.05). The brain (olfactory bulb) levels of MT after intranasal administration were 9.22, 6.77 and 4.04-fold higher for carbopol, CMC and PEG400, respectively, than that of intravenous MT in rats. In conclusion, microdialysis studies demonstrated increased brain levels of MT via nasal administration in rats." @default.
- W2030772020 created "2016-06-24" @default.
- W2030772020 creator A5055704882 @default.
- W2030772020 creator A5057334787 @default.
- W2030772020 creator A5071215928 @default.
- W2030772020 creator A5080409467 @default.
- W2030772020 date "2011-03-23" @default.
- W2030772020 modified "2023-09-24" @default.
- W2030772020 title "Nose-to-brain transport of melatonin from polymer gel suspensions: a microdialysis study in rats" @default.
- W2030772020 cites W1485916853 @default.
- W2030772020 cites W1527910050 @default.
- W2030772020 cites W1965690769 @default.
- W2030772020 cites W1967419252 @default.
- W2030772020 cites W1968427961 @default.
- W2030772020 cites W1968632820 @default.
- W2030772020 cites W1969982341 @default.
- W2030772020 cites W1976458502 @default.
- W2030772020 cites W1980673490 @default.
- W2030772020 cites W1981359936 @default.
- W2030772020 cites W1993115176 @default.
- W2030772020 cites W1993421387 @default.
- W2030772020 cites W1997504565 @default.
- W2030772020 cites W2001525797 @default.
- W2030772020 cites W2003021017 @default.
- W2030772020 cites W2018340655 @default.
- W2030772020 cites W2020648990 @default.
- W2030772020 cites W2035236504 @default.
- W2030772020 cites W2035536790 @default.
- W2030772020 cites W2041145659 @default.
- W2030772020 cites W2041625419 @default.
- W2030772020 cites W2043646512 @default.
- W2030772020 cites W2044968935 @default.
- W2030772020 cites W2048428155 @default.
- W2030772020 cites W2050167321 @default.
- W2030772020 cites W2062449437 @default.
- W2030772020 cites W2063991495 @default.
- W2030772020 cites W2066872194 @default.
- W2030772020 cites W2066875055 @default.
- W2030772020 cites W2068913648 @default.
- W2030772020 cites W2071794509 @default.
- W2030772020 cites W2083337622 @default.
- W2030772020 cites W2086190854 @default.
- W2030772020 cites W2086776758 @default.
- W2030772020 cites W2101613977 @default.
- W2030772020 cites W2121858140 @default.
- W2030772020 cites W2123541107 @default.
- W2030772020 cites W2137034584 @default.
- W2030772020 cites W2144789366 @default.
- W2030772020 cites W2150958254 @default.
- W2030772020 cites W2154269061 @default.
- W2030772020 cites W2155644613 @default.
- W2030772020 cites W2156600347 @default.
- W2030772020 cites W2157464601 @default.
- W2030772020 cites W2159517627 @default.
- W2030772020 cites W2163771644 @default.
- W2030772020 cites W2165912710 @default.
- W2030772020 cites W2171359294 @default.
- W2030772020 cites W2317722061 @default.
- W2030772020 cites W2318375363 @default.
- W2030772020 cites W29488080 @default.
- W2030772020 cites W4243621715 @default.
- W2030772020 cites W703482 @default.
- W2030772020 doi "https://doi.org/10.3109/1061186x.2011.558090" @default.
- W2030772020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3334865" @default.
- W2030772020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21428693" @default.
- W2030772020 hasPublicationYear "2011" @default.
- W2030772020 type Work @default.
- W2030772020 sameAs 2030772020 @default.
- W2030772020 citedByCount "22" @default.
- W2030772020 countsByYear W20307720202012 @default.
- W2030772020 countsByYear W20307720202013 @default.
- W2030772020 countsByYear W20307720202014 @default.
- W2030772020 countsByYear W20307720202015 @default.
- W2030772020 countsByYear W20307720202017 @default.
- W2030772020 countsByYear W20307720202018 @default.
- W2030772020 countsByYear W20307720202019 @default.
- W2030772020 countsByYear W20307720202020 @default.
- W2030772020 countsByYear W20307720202021 @default.
- W2030772020 countsByYear W20307720202022 @default.
- W2030772020 crossrefType "journal-article" @default.
- W2030772020 hasAuthorship W2030772020A5055704882 @default.
- W2030772020 hasAuthorship W2030772020A5057334787 @default.
- W2030772020 hasAuthorship W2030772020A5071215928 @default.
- W2030772020 hasAuthorship W2030772020A5080409467 @default.
- W2030772020 hasBestOaLocation W20307720202 @default.
- W2030772020 hasConcept C126322002 @default.
- W2030772020 hasConcept C178790620 @default.
- W2030772020 hasConcept C185592680 @default.
- W2030772020 hasConcept C2776035855 @default.
- W2030772020 hasConcept C2776081644 @default.
- W2030772020 hasConcept C2776964284 @default.
- W2030772020 hasConcept C2778182776 @default.
- W2030772020 hasConcept C28406088 @default.
- W2030772020 hasConcept C43617362 @default.
- W2030772020 hasConcept C50156730 @default.
- W2030772020 hasConcept C521977710 @default.
- W2030772020 hasConcept C537181965 @default.
- W2030772020 hasConcept C55493867 @default.