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• W2030778459 abstract "The global obesity epidemic is associated with a series of health-threatening diseases including type 2 diabetes. Accumulating evidence suggest that the physiology and homeostasis of the endoplasmic reticulum (ER) is intimately involved in the underlying mechanisms linking obesity and diabetes. Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Focusing on the IRE1α–XBP1 pathway, we review recent advances in our understanding of the role of UPR in obesity and obesity-associated metabolic disorders." @default.
• W2030778459 created "2016-06-24" @default.
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• W2030778459 date "2011-09-01" @default.
• W2030778459 modified "2023-10-15" @default.
• W2030778459 title "Stressed out about obesity: IRE1α–XBP1 in metabolic disorders" @default.
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• W2030778459 doi "https://doi.org/10.1016/j.tem.2011.05.002" @default.
• W2030778459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3163776" @default.
• W2030778459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21703863" @default.
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