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- W2030783903 abstract "A first derivative spectrophotometric method was developed for the determination of omeprazole in aqueous solutions during stability studies. The derivative procedure was based on the linear relationship between the omeprazole concentration and the first derivative amplitude at 313 nm. The first derivative spectra was developed between 200 and 400 nm (deltalambda = 8). This method was validated and compared with the official high-performance liquid chromatography (HPLC) method of the USP. It showed good linearity in the range of concentrations studied (10-30 microg ml(-1)), precision (repeatability and inter-day reproducibility), recovery and specificity in stability studies. It also seemed to be 2.59 times more sensitive than the HPLC method. These results allowed to consider this procedure as useful for the rapid analysis of omeprazole in stability studies since there was no interference with its decomposition products." @default.
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- W2030783903 date "1999-11-01" @default.
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- W2030783903 title "Comparison of derivative spectrophotometric and liquid chromatograpic methods for the determination of omeprazole in aqueous solutions during stability studies" @default.
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- W2030783903 doi "https://doi.org/10.1016/s0731-7085(99)00136-3" @default.
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