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• W2030788682 abstract "Glutamate, a major excitatory neurotransmitter, has been implicated as an important mediator in the neurotransmission, potentiation, and negative affect associated with pain. We present results showing that a painful stimulus elicits a dynamic increase in glutamate (9.3% from baseline) concentrations in the anterior cingulate cortex, detectable using proton Magnetic Resonance Spectroscopy (1H-MRS). Increases in glutamine levels were also seen, which correlate strongly with the subjective level of pain experienced by participants (r2 = 0.58, P < 0.01). These novel findings are the first time a dynamic change in glutamate and glutamine levels from baseline in response to an external stimuli has been measured in a single proton MRS scanning session. As such, this report demonstrates the efficacy of 1H-MRS as a non-invasive tool for the study of neural responses to pain in vivo. The paradigm used in this study demonstrates that dynamic glutamate/glutamine changes due to stimulation are measurable by proton MRS, and could provide a means of testing novel pharmaceutical agents and other treatments for chronic pain." @default.
• W2030788682 created "2016-06-24" @default.
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• W2030788682 date "2005-06-01" @default.
• W2030788682 modified "2023-10-09" @default.
• W2030788682 title "A novel technique to study the brain's response to pain: Proton magnetic resonance spectroscopy" @default.
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• W2030788682 doi "https://doi.org/10.1016/j.neuroimage.2005.02.001" @default.
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