FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030789035> ?p ?o ?g. }

• W2030789035 endingPage "180" @default.
• W2030789035 startingPage "171" @default.
• W2030789035 abstract "Investigations have been undertaken in order to study the possibility that Lanthanum could differently affect the different calcium binding sites. Experiments have been carried out in normal and in K+-depolarized rat uterus. A biphasic action (inhibition of the concentration which wears off at higher doses) is shown by Lanthanum. The suggestion that this dual effect could correspond to a dual site of action (cell membrane and intracellular calcium stores) seems to be confirmed by the enhancement of contraction occurring at high Lanthanum concentrations in depolarized preparations. Finally, the contractions elicited by Lanthanum in Ca-free, K+-depolarized preparations suggest that Lanthanum can penetrate into the cells and bind to the contractile elements, acting as a calcium substitute. The activation of the contractile elements in smooth as well as in skeletal muscles involves the increase of calcium concentration in cytoplasm (Hurwitz, 1971) above 10−7 M (Bianchi, 1969). Activator calcium may come from intracellular storage sites (Carsten, 1969; Peachey et al., 1959), or from extracellular sources; the last process could become more evident when the cell permeability is enhanced, like during the depolarization of the cell membrane (Hurwitz, 1971). A direct proof of the involvement of one or both mechanisms is difficult to obtain, since a small increase in tissue calcium content is needed for maximal activation of contractile elements; to this purpose a new method has been recently proposed. The method is based on the use of Lanthanum, making the assumption that this element, whose affinity for negative groups is higher than that of calcium, can displace calcium from the membrane-located binding sites; because of the apparent ability to limit its action at the level of the membrane, Lanthanum could effectively “lock in” the intracellular calcium and block the calcium movements across the membrane (Marschall, 1973). Since all conclusions drawn by the Lanthanum method are based on the assumption that the activity of this element is limited to a calcium displacement from the cell membrane, further investigations are needed in order to check if Lanthanum can penetrate into the cell and in this case which effect it brings about. In fact, some observations (Goodman et al., 1971) let suggest that Lanthanum could differently affect the different calcium sites or stores. In these experiments, the action of Lanthanum on smooth muscles has been studied in control conditions and after depolarization, i.e. by normal and by enhanced membrane permeability. Rat uterus has been choosen as the target organ since it develops spontaneous contractions which can be used for evaluating the action of an inhibiting agent." @default.
• W2030789035 created "2016-06-24" @default.
• W2030789035 creator A5032427972 @default.
• W2030789035 creator A5046395736 @default.
• W2030789035 creator A5065246333 @default.
• W2030789035 creator A5089708690 @default.
• W2030789035 date "1975-04-01" @default.
• W2030789035 modified "2023-09-27" @default.
• W2030789035 title "Diphasic action of lanthanum in rat uterus" @default.
• W2030789035 cites W1998336212 @default.
• W2030789035 cites W2046575779 @default.
• W2030789035 cites W2058406193 @default.
• W2030789035 cites W2108091678 @default.
• W2030789035 cites W2164752363 @default.
• W2030789035 cites W2174751052 @default.
• W2030789035 cites W2175345051 @default.
• W2030789035 cites W2409900293 @default.
• W2030789035 doi "https://doi.org/10.1016/s0031-6989(75)80021-x" @default.
• W2030789035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1144493" @default.
• W2030789035 hasPublicationYear "1975" @default.
• W2030789035 type Work @default.
• W2030789035 sameAs 2030789035 @default.
• W2030789035 citedByCount "6" @default.
• W2030789035 crossrefType "journal-article" @default.
• W2030789035 hasAuthorship W2030789035A5032427972 @default.
• W2030789035 hasAuthorship W2030789035A5046395736 @default.
• W2030789035 hasAuthorship W2030789035A5065246333 @default.
• W2030789035 hasAuthorship W2030789035A5089708690 @default.
• W2030789035 hasConcept C12554922 @default.
• W2030789035 hasConcept C126322002 @default.
• W2030789035 hasConcept C134018914 @default.
• W2030789035 hasConcept C163415756 @default.
• W2030789035 hasConcept C170493617 @default.
• W2030789035 hasConcept C178790620 @default.
• W2030789035 hasConcept C179104552 @default.
• W2030789035 hasConcept C181080969 @default.
• W2030789035 hasConcept C185592680 @default.
• W2030789035 hasConcept C28406088 @default.
• W2030789035 hasConcept C2992270614 @default.
• W2030789035 hasConcept C4141045 @default.
• W2030789035 hasConcept C41625074 @default.
• W2030789035 hasConcept C519063684 @default.
• W2030789035 hasConcept C55493867 @default.
• W2030789035 hasConcept C555894677 @default.
• W2030789035 hasConcept C71924100 @default.
• W2030789035 hasConcept C79879829 @default.
• W2030789035 hasConcept C86803240 @default.
• W2030789035 hasConcept C88045685 @default.
• W2030789035 hasConceptScore W2030789035C12554922 @default.
• W2030789035 hasConceptScore W2030789035C126322002 @default.
• W2030789035 hasConceptScore W2030789035C134018914 @default.
• W2030789035 hasConceptScore W2030789035C163415756 @default.
• W2030789035 hasConceptScore W2030789035C170493617 @default.
• W2030789035 hasConceptScore W2030789035C178790620 @default.
• W2030789035 hasConceptScore W2030789035C179104552 @default.
• W2030789035 hasConceptScore W2030789035C181080969 @default.
• W2030789035 hasConceptScore W2030789035C185592680 @default.
• W2030789035 hasConceptScore W2030789035C28406088 @default.
• W2030789035 hasConceptScore W2030789035C2992270614 @default.
• W2030789035 hasConceptScore W2030789035C4141045 @default.
• W2030789035 hasConceptScore W2030789035C41625074 @default.
• W2030789035 hasConceptScore W2030789035C519063684 @default.
• W2030789035 hasConceptScore W2030789035C55493867 @default.
• W2030789035 hasConceptScore W2030789035C555894677 @default.
• W2030789035 hasConceptScore W2030789035C71924100 @default.
• W2030789035 hasConceptScore W2030789035C79879829 @default.
• W2030789035 hasConceptScore W2030789035C86803240 @default.
• W2030789035 hasConceptScore W2030789035C88045685 @default.
• W2030789035 hasIssue "2" @default.
• W2030789035 hasLocation W20307890351 @default.
• W2030789035 hasLocation W20307890352 @default.
• W2030789035 hasOpenAccess W2030789035 @default.
• W2030789035 hasPrimaryLocation W20307890351 @default.
• W2030789035 hasRelatedWork W139870775 @default.
• W2030789035 hasRelatedWork W1995216096 @default.
• W2030789035 hasRelatedWork W2030789035 @default.
• W2030789035 hasRelatedWork W2032484627 @default.
• W2030789035 hasRelatedWork W2065475705 @default.
• W2030789035 hasRelatedWork W2070090930 @default.
• W2030789035 hasRelatedWork W2085920417 @default.
• W2030789035 hasRelatedWork W2139429373 @default.
• W2030789035 hasRelatedWork W2162032112 @default.
• W2030789035 hasRelatedWork W2274238791 @default.
• W2030789035 hasVolume "7" @default.
• W2030789035 isParatext "false" @default.
• W2030789035 isRetracted "false" @default.
• W2030789035 magId "2030789035" @default.
• W2030789035 workType "article" @default.