FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030791966> ?p ?o ?g. }

• W2030791966 endingPage "516" @default.
• W2030791966 startingPage "511" @default.
• W2030791966 abstract "We studied the interaction of azole antimycotics with intravenous (IV) and oral midazolam using a cross-over design in 12 volunteers, who ingested placebo, itraconazole, or fluconazole for 6 days. A 7.5-mg dose of midazolam was ingested on the first day, 0.05 mg/kg was administered IV on the fourth day, and 7.5 mg orally on the sixth day. Itraconazole reduced the clearance of IV midazolam by 69% and fluconazole reduced the clearance of IV midazolam by 51% (P < 0.001). A single dose of itraconazole and fluconazole increased the area under the oral midazolam concentration-time curve [AUC(0-infinity)] 3.5-fold (P < 0.001) and the peak concentration two-fold (P < 0.05) compared to placebo. On the sixth day the AUC(0-infinity) of oral midazolam was almost seven times greater with itraconazole (P < 0.001) and 3.6 times greater with fluconazole (P < 0.001) than without the antimycotics. The psychomotor effects of midazolam were also profoundly increased (P < 0.001). The psychomotor tests demonstrated only a weak interaction between the antimycotics and IV midazolam. When bolus doses of midazolam are given for short- time sedation, the effect of midazolam is not increased to a clinically significant degree by itraconazole and fluconazole, and it can be used in normal doses. However, the use of large doses of IV midazolam increases the risk of clinically significant interactions also after IV midazolam. Use of oral midazolam with itraconazole and fluconazole should be avoided." @default.
• W2030791966 created "2016-06-24" @default.
• W2030791966 creator A5039947544 @default.
• W2030791966 creator A5089475081 @default.
• W2030791966 creator A5091721438 @default.
• W2030791966 date "1996-03-01" @default.
• W2030791966 modified "2023-10-16" @default.
• W2030791966 title "The Effect of the Systemic Antimycotics, Itraconazole and Fluconazole, on the Pharmacokinetics and Pharmacodynamics of Intravenous and Oral Midazolam" @default.
• W2030791966 cites W1984175249 @default.
• W2030791966 cites W1987051504 @default.
• W2030791966 cites W2004576165 @default.
• W2030791966 cites W2017573139 @default.
• W2030791966 cites W2030488800 @default.
• W2030791966 cites W2030503504 @default.
• W2030791966 cites W2040869398 @default.
• W2030791966 cites W2054040800 @default.
• W2030791966 cites W2056900917 @default.
• W2030791966 cites W2067525361 @default.
• W2030791966 cites W2069326210 @default.
• W2030791966 cites W2104093795 @default.
• W2030791966 cites W2105681476 @default.
• W2030791966 cites W2127288395 @default.
• W2030791966 doi "https://doi.org/10.1097/00000539-199603000-00015" @default.
• W2030791966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8623953" @default.
• W2030791966 hasPublicationYear "1996" @default.
• W2030791966 type Work @default.
• W2030791966 sameAs 2030791966 @default.
• W2030791966 citedByCount "110" @default.
• W2030791966 countsByYear W20307919662012 @default.
• W2030791966 countsByYear W20307919662013 @default.
• W2030791966 countsByYear W20307919662014 @default.
• W2030791966 countsByYear W20307919662015 @default.
• W2030791966 countsByYear W20307919662016 @default.
• W2030791966 countsByYear W20307919662017 @default.
• W2030791966 countsByYear W20307919662018 @default.
• W2030791966 countsByYear W20307919662019 @default.
• W2030791966 countsByYear W20307919662020 @default.
• W2030791966 countsByYear W20307919662021 @default.
• W2030791966 countsByYear W20307919662022 @default.
• W2030791966 countsByYear W20307919662023 @default.
• W2030791966 crossrefType "journal-article" @default.
• W2030791966 hasAuthorship W2030791966A5039947544 @default.
• W2030791966 hasAuthorship W2030791966A5089475081 @default.
• W2030791966 hasAuthorship W2030791966A5091721438 @default.
• W2030791966 hasBestOaLocation W20307919661 @default.
• W2030791966 hasConcept C111113717 @default.
• W2030791966 hasConcept C112705442 @default.
• W2030791966 hasConcept C142724271 @default.
• W2030791966 hasConcept C16005928 @default.
• W2030791966 hasConcept C204787440 @default.
• W2030791966 hasConcept C27081682 @default.
• W2030791966 hasConcept C2776814716 @default.
• W2030791966 hasConcept C2777056448 @default.
• W2030791966 hasConcept C2777071850 @default.
• W2030791966 hasConcept C2778000748 @default.
• W2030791966 hasConcept C2779548794 @default.
• W2030791966 hasConcept C2780651595 @default.
• W2030791966 hasConcept C2780734495 @default.
• W2030791966 hasConcept C42219234 @default.
• W2030791966 hasConcept C71924100 @default.
• W2030791966 hasConcept C87813604 @default.
• W2030791966 hasConcept C97320921 @default.
• W2030791966 hasConcept C98274493 @default.
• W2030791966 hasConceptScore W2030791966C111113717 @default.
• W2030791966 hasConceptScore W2030791966C112705442 @default.
• W2030791966 hasConceptScore W2030791966C142724271 @default.
• W2030791966 hasConceptScore W2030791966C16005928 @default.
• W2030791966 hasConceptScore W2030791966C204787440 @default.
• W2030791966 hasConceptScore W2030791966C27081682 @default.
• W2030791966 hasConceptScore W2030791966C2776814716 @default.
• W2030791966 hasConceptScore W2030791966C2777056448 @default.
• W2030791966 hasConceptScore W2030791966C2777071850 @default.
• W2030791966 hasConceptScore W2030791966C2778000748 @default.
• W2030791966 hasConceptScore W2030791966C2779548794 @default.
• W2030791966 hasConceptScore W2030791966C2780651595 @default.
• W2030791966 hasConceptScore W2030791966C2780734495 @default.
• W2030791966 hasConceptScore W2030791966C42219234 @default.
• W2030791966 hasConceptScore W2030791966C71924100 @default.
• W2030791966 hasConceptScore W2030791966C87813604 @default.
• W2030791966 hasConceptScore W2030791966C97320921 @default.
• W2030791966 hasConceptScore W2030791966C98274493 @default.
• W2030791966 hasIssue "3" @default.
• W2030791966 hasLocation W20307919661 @default.
• W2030791966 hasLocation W20307919662 @default.
• W2030791966 hasLocation W20307919663 @default.
• W2030791966 hasOpenAccess W2030791966 @default.
• W2030791966 hasPrimaryLocation W20307919661 @default.
• W2030791966 hasRelatedWork W1971830765 @default.
• W2030791966 hasRelatedWork W2025740386 @default.
• W2030791966 hasRelatedWork W2030791966 @default.
• W2030791966 hasRelatedWork W2146507402 @default.
• W2030791966 hasRelatedWork W2157262647 @default.
• W2030791966 hasRelatedWork W2531277573 @default.
• W2030791966 hasRelatedWork W2766550598 @default.
• W2030791966 hasRelatedWork W2783654850 @default.
• W2030791966 hasRelatedWork W3085943042 @default.
• W2030791966 hasRelatedWork W4247118969 @default.
• W2030791966 hasVolume "82" @default.

• next