FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030793158> ?p ?o ?g. }

• W2030793158 endingPage "545" @default.
• W2030793158 startingPage "541" @default.
• W2030793158 abstract "Microvascular dysfunction occurs in Type 2 diabetes and in subjects with fasting hyperglycaemia. It is unclear whether this dysfunction relates to dysglycaemia. This study investigated in normogylcaemic individuals whether a genetic predisposition to diabetes, or indices of insulin resistance including endothelial markers, were associated with impaired microvascular function.Maximum microvascular hyperaemia to local heating of the skin was measured using laser Doppler flowmetry in 21 normoglycaemic subjects with no family history of diabetes (Group 1) and 21 normoglycaemic age, sex and body mass index-matched offspring of two parents with Type 2 diabetes (Group 2).Although Group 2 had normal fasting plasma glucose and glucose tolerance tests, the 120-min glucose values were significantly higher at 6.4 (5.3-6.6) mmol/l (median (25th - 75th centile)) than the control group at 4.9 (4.6-5.9) mmol/l (P = 0.005) and the insulinogenic index was lower at 97.1 (60.9-130.8) vs. 124.0 (97.2-177.7) (P = 0.027). Skin maximum microvascular hyperaemia (Group 1: 1.56 (1.39-1.80) vs. Group 2: 1.53 (1.30-1.98) V, P = 0.99) and minimum microvascular resistance which normalizes the hyperaemia data for blood pressure (Group 1: 52.0 (43.2-67.4) vs. Group 2: 56.0 (43.7-69.6) mmHg/V, P = 0.70) did not differ in the two groups. Significant positive associations occurred between minimum microvascular resistance and indices of the insulin resistance syndrome; plasminogen activator inhibitor type 1 (R(s) = 0.46, P = 0.003), t-PA (R(s) = 0.36, P = 0.03), total cholesterol (R(s) = 0.35, P = 0.02), and triglyceride concentration (R(s) = 0.35, P = 0.02), and an inverse association with insulin sensitivity (R(s) = -0.33, P = 0.03).In normoglycaemic adults cutaneous microvascular vasodilatory capacity is associated with features of insulin resistance syndrome, particularly with plasminogen activator inhibitor type 1. A strong family history of Type 2 diabetes alone does not result in impairment in the maximum hyperaemic response. Diabet. Med. 18, 541-545 (2001)" @default.
• W2030793158 created "2016-06-24" @default.
• W2030793158 creator A5006858303 @default.
• W2030793158 creator A5011301357 @default.
• W2030793158 creator A5014043624 @default.
• W2030793158 creator A5042717392 @default.
• W2030793158 creator A5052659473 @default.
• W2030793158 creator A5060736941 @default.
• W2030793158 creator A5072883388 @default.
• W2030793158 creator A5088521526 @default.
• W2030793158 date "2001-07-01" @default.
• W2030793158 modified "2023-10-18" @default.
• W2030793158 title "Skin microvascular vasodilatory capacity in offspring of two parents with Type 2 diabetes" @default.
• W2030793158 cites W175652702 @default.
• W2030793158 cites W1977504640 @default.
• W2030793158 cites W1991403690 @default.
• W2030793158 cites W1996174384 @default.
• W2030793158 cites W200179319 @default.
• W2030793158 cites W2003300161 @default.
• W2030793158 cites W2025755388 @default.
• W2030793158 cites W2040538689 @default.
• W2030793158 cites W2066898102 @default.
• W2030793158 cites W2069543924 @default.
• W2030793158 cites W2083910569 @default.
• W2030793158 cites W2102131871 @default.
• W2030793158 cites W2151172803 @default.
• W2030793158 cites W2155048443 @default.
• W2030793158 cites W2160234571 @default.
• W2030793158 cites W2163376944 @default.
• W2030793158 cites W4256711533 @default.
• W2030793158 cites W4321059897 @default.
• W2030793158 doi "https://doi.org/10.1046/j.1464-5491.2001.00514.x" @default.
• W2030793158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11553182" @default.
• W2030793158 hasPublicationYear "2001" @default.
• W2030793158 type Work @default.
• W2030793158 sameAs 2030793158 @default.
• W2030793158 citedByCount "19" @default.
• W2030793158 countsByYear W20307931582012 @default.
• W2030793158 countsByYear W20307931582014 @default.
• W2030793158 countsByYear W20307931582015 @default.
• W2030793158 countsByYear W20307931582018 @default.
• W2030793158 countsByYear W20307931582021 @default.
• W2030793158 crossrefType "journal-article" @default.
• W2030793158 hasAuthorship W2030793158A5006858303 @default.
• W2030793158 hasAuthorship W2030793158A5011301357 @default.
• W2030793158 hasAuthorship W2030793158A5014043624 @default.
• W2030793158 hasAuthorship W2030793158A5042717392 @default.
• W2030793158 hasAuthorship W2030793158A5052659473 @default.
• W2030793158 hasAuthorship W2030793158A5060736941 @default.
• W2030793158 hasAuthorship W2030793158A5072883388 @default.
• W2030793158 hasAuthorship W2030793158A5088521526 @default.
• W2030793158 hasBestOaLocation W20307931582 @default.
• W2030793158 hasConcept C112672928 @default.
• W2030793158 hasConcept C120770815 @default.
• W2030793158 hasConcept C126322002 @default.
• W2030793158 hasConcept C134018914 @default.
• W2030793158 hasConcept C158846371 @default.
• W2030793158 hasConcept C2777180221 @default.
• W2030793158 hasConcept C2777391703 @default.
• W2030793158 hasConcept C2777691872 @default.
• W2030793158 hasConcept C2779234561 @default.
• W2030793158 hasConcept C2779679481 @default.
• W2030793158 hasConcept C2780221984 @default.
• W2030793158 hasConcept C2780609358 @default.
• W2030793158 hasConcept C2780972559 @default.
• W2030793158 hasConcept C54355233 @default.
• W2030793158 hasConcept C555293320 @default.
• W2030793158 hasConcept C71924100 @default.
• W2030793158 hasConcept C86803240 @default.
• W2030793158 hasConceptScore W2030793158C112672928 @default.
• W2030793158 hasConceptScore W2030793158C120770815 @default.
• W2030793158 hasConceptScore W2030793158C126322002 @default.
• W2030793158 hasConceptScore W2030793158C134018914 @default.
• W2030793158 hasConceptScore W2030793158C158846371 @default.
• W2030793158 hasConceptScore W2030793158C2777180221 @default.
• W2030793158 hasConceptScore W2030793158C2777391703 @default.
• W2030793158 hasConceptScore W2030793158C2777691872 @default.
• W2030793158 hasConceptScore W2030793158C2779234561 @default.
• W2030793158 hasConceptScore W2030793158C2779679481 @default.
• W2030793158 hasConceptScore W2030793158C2780221984 @default.
• W2030793158 hasConceptScore W2030793158C2780609358 @default.
• W2030793158 hasConceptScore W2030793158C2780972559 @default.
• W2030793158 hasConceptScore W2030793158C54355233 @default.
• W2030793158 hasConceptScore W2030793158C555293320 @default.
• W2030793158 hasConceptScore W2030793158C71924100 @default.
• W2030793158 hasConceptScore W2030793158C86803240 @default.
• W2030793158 hasIssue "7" @default.
• W2030793158 hasLocation W20307931581 @default.
• W2030793158 hasLocation W20307931582 @default.
• W2030793158 hasLocation W20307931583 @default.
• W2030793158 hasOpenAccess W2030793158 @default.
• W2030793158 hasPrimaryLocation W20307931581 @default.
• W2030793158 hasRelatedWork W1838813243 @default.
• W2030793158 hasRelatedWork W1979699657 @default.
• W2030793158 hasRelatedWork W1994716404 @default.
• W2030793158 hasRelatedWork W2054509127 @default.
• W2030793158 hasRelatedWork W2056137474 @default.
• W2030793158 hasRelatedWork W2063506869 @default.

• next