FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030799274> ?p ?o ?g. }

• W2030799274 endingPage "661" @default.
• W2030799274 startingPage "653" @default.
• W2030799274 abstract "Endomorphin-2 (Tyr-Pro-Phe-PheNH(2)) was discovered as an endogenous ligand for the mu-opioid receptor. The physiological function of endomorphin-2 as a neurotransmitter or neuromodulator may cease through the rapid enzymatic process in the synapse of brain, as for other neuropeptides. The present study was conducted to examine the metabolism of endomorphin-2 by synaptic membranes prepared from mouse brain. Major metabolites were free tyrosine, free phenylalanine, Tyr-Pro and PheNH(2). Both the degradation of endomorphin-2 and the accumulation of major metabolites were inhibited by specific inhibitors of dipeptidyl peptidase IV, such as diprotin A and B. On the other hand, the accumulation of Phe-PheNH(2) and Pro-Phe-PheNH(2) was increased in the presence of bestatin, an aminopeptidase inhibitor, whereas that of free phenylalanine and PheNH(2) was decreased. Furthermore, purified dipeptidyl peptidase IV hydrolyzed endomorphin-2 at the cleavage site, Pro(2)-Phe(3) bond. Thus, degradation of endomorphin-2 by brain synaptic membranes seems to take place mainly through the cleavage of Pro(2)-Phe(3) bond by dipeptidyl peptidase IV, followed by release of free phenylalanine and PheNH(2) from the liberated fragment, Phe-PheNH(2) by aminopeptidase. We have also examined that the effect of diprotin A on the antinociception induced by intracerebroventricularly administered endomorphin-2 in the mouse paw withdrawal test. Diprotin A simultaneously injected with endomorphin-2 enhanced endomorphin-2-induced antinociception. These results indicate that dipeptidyl peptidase IV may be an important peptidase responsible for terminating endomorphin-2-induced antinociception at the supraspinal level in mice." @default.
• W2030799274 created "2016-06-24" @default.
• W2030799274 creator A5008797828 @default.
• W2030799274 creator A5015697653 @default.
• W2030799274 creator A5022816179 @default.
• W2030799274 creator A5049438575 @default.
• W2030799274 creator A5060396150 @default.
• W2030799274 creator A5068482988 @default.
• W2030799274 date "2003-08-01" @default.
• W2030799274 modified "2023-09-26" @default.
• W2030799274 title "Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study" @default.
• W2030799274 cites W1829933729 @default.
• W2030799274 cites W1967647423 @default.
• W2030799274 cites W1975262853 @default.
• W2030799274 cites W1980281407 @default.
• W2030799274 cites W1980410333 @default.
• W2030799274 cites W1986751279 @default.
• W2030799274 cites W2002775774 @default.
• W2030799274 cites W2017090169 @default.
• W2030799274 cites W2031468509 @default.
• W2030799274 cites W2034351494 @default.
• W2030799274 cites W2036049344 @default.
• W2030799274 cites W2039704972 @default.
• W2030799274 cites W2065458147 @default.
• W2030799274 cites W2071481472 @default.
• W2030799274 cites W2079681415 @default.
• W2030799274 cites W2087454739 @default.
• W2030799274 cites W2093110345 @default.
• W2030799274 cites W2093618119 @default.
• W2030799274 cites W2094973127 @default.
• W2030799274 cites W2161909946 @default.
• W2030799274 cites W2328743798 @default.
• W2030799274 cites W3104056310 @default.
• W2030799274 cites W4236702479 @default.
• W2030799274 cites W4293247451 @default.
• W2030799274 doi "https://doi.org/10.1016/s0006-2952(03)00391-5" @default.
• W2030799274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12906930" @default.
• W2030799274 hasPublicationYear "2003" @default.
• W2030799274 type Work @default.
• W2030799274 sameAs 2030799274 @default.
• W2030799274 citedByCount "51" @default.
• W2030799274 countsByYear W20307992742012 @default.
• W2030799274 countsByYear W20307992742013 @default.
• W2030799274 countsByYear W20307992742014 @default.
• W2030799274 countsByYear W20307992742015 @default.
• W2030799274 countsByYear W20307992742016 @default.
• W2030799274 countsByYear W20307992742020 @default.
• W2030799274 countsByYear W20307992742022 @default.
• W2030799274 countsByYear W20307992742023 @default.
• W2030799274 crossrefType "journal-article" @default.
• W2030799274 hasAuthorship W2030799274A5008797828 @default.
• W2030799274 hasAuthorship W2030799274A5015697653 @default.
• W2030799274 hasAuthorship W2030799274A5022816179 @default.
• W2030799274 hasAuthorship W2030799274A5049438575 @default.
• W2030799274 hasAuthorship W2030799274A5060396150 @default.
• W2030799274 hasAuthorship W2030799274A5068482988 @default.
• W2030799274 hasConcept C104826730 @default.
• W2030799274 hasConcept C134018914 @default.
• W2030799274 hasConcept C150903083 @default.
• W2030799274 hasConcept C156490143 @default.
• W2030799274 hasConcept C170493617 @default.
• W2030799274 hasConcept C181199279 @default.
• W2030799274 hasConcept C185592680 @default.
• W2030799274 hasConcept C207001950 @default.
• W2030799274 hasConcept C2776401185 @default.
• W2030799274 hasConcept C2776580952 @default.
• W2030799274 hasConcept C2777180221 @default.
• W2030799274 hasConcept C2777431362 @default.
• W2030799274 hasConcept C2777803847 @default.
• W2030799274 hasConcept C2780985610 @default.
• W2030799274 hasConcept C2781063702 @default.
• W2030799274 hasConcept C2781372283 @default.
• W2030799274 hasConcept C2781469919 @default.
• W2030799274 hasConcept C515207424 @default.
• W2030799274 hasConcept C55493867 @default.
• W2030799274 hasConcept C555293320 @default.
• W2030799274 hasConcept C86803240 @default.
• W2030799274 hasConcept C88016717 @default.
• W2030799274 hasConceptScore W2030799274C104826730 @default.
• W2030799274 hasConceptScore W2030799274C134018914 @default.
• W2030799274 hasConceptScore W2030799274C150903083 @default.
• W2030799274 hasConceptScore W2030799274C156490143 @default.
• W2030799274 hasConceptScore W2030799274C170493617 @default.
• W2030799274 hasConceptScore W2030799274C181199279 @default.
• W2030799274 hasConceptScore W2030799274C185592680 @default.
• W2030799274 hasConceptScore W2030799274C207001950 @default.
• W2030799274 hasConceptScore W2030799274C2776401185 @default.
• W2030799274 hasConceptScore W2030799274C2776580952 @default.
• W2030799274 hasConceptScore W2030799274C2777180221 @default.
• W2030799274 hasConceptScore W2030799274C2777431362 @default.
• W2030799274 hasConceptScore W2030799274C2777803847 @default.
• W2030799274 hasConceptScore W2030799274C2780985610 @default.
• W2030799274 hasConceptScore W2030799274C2781063702 @default.
• W2030799274 hasConceptScore W2030799274C2781372283 @default.
• W2030799274 hasConceptScore W2030799274C2781469919 @default.
• W2030799274 hasConceptScore W2030799274C515207424 @default.
• W2030799274 hasConceptScore W2030799274C55493867 @default.
• W2030799274 hasConceptScore W2030799274C555293320 @default.

• next