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• W2030804582 startingPage "206" @default.
• W2030804582 abstract "Vasoactive intestinal peptide (VIP) is a naturally occurring neuropeptide widely distributed in the nervous system. In this study, we investigated the effect of VIP on IL-12, TNF alpha and nitric oxide (NO) production in macrophages following activation with lipopolysaccharide (LPS) or superantigens. In vitro studies show that at physiologic concentrations, VIP inhibited IL-12 and NO but not TNF alpha production in macrophages which were stimulated with LPS or superantigens. The inhibitory effect of VIP on IL-12 production appeared to be cAMP mediated since other cAMP inducing agents were also potent in inhibiting IL-12 production. Since IL-12 plays a critical role in T cell function, we suggest that naturally occurring neural hormones can regulate the type and direction of the immune response." @default.
• W2030804582 created "2016-06-24" @default.
• W2030804582 creator A5025340186 @default.
• W2030804582 creator A5042412445 @default.
• W2030804582 date "1998-08-01" @default.
• W2030804582 modified "2023-09-27" @default.
• W2030804582 title "Vasoactive intestinal peptide inhibits IL-12 and nitric oxide production in murine macrophages" @default.
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• W2030804582 doi "https://doi.org/10.1016/s0165-5728(98)00140-4" @default.
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