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- W2030805520 abstract "Patients after hematopoietic cell transplantation lack naı̈ve T cells because of insufficient generation of T cells de novo (thymopoiesis). Ways to improve de novo generation have recently been studied, using, e.g., prothymopoietic cytokines or a thymic organoid (“artificial thymus”). It is not known whether improved thymopoiesis might result in more T cells only for pathogens that are typically absent from the body (e.g., neopathogens like ebola virus or cleared recall pathogens like measles virus) or also for pathogens or malignant cells present in the body (e.g., herpesviruses that infected the host pretransplant or the leukemia that necessitated hematopoietic cell transplantation). The latter T cells may be more important, as posttransplant infections due to endogenous microorganisms (e.g., herpesviruses) and leukemic relapse cause major morbidity and mortality. However, T cells recognizing self-peptides should theoretically be deleted in the thymus by negative selection. Peptides from the endogenous viruses or leukemic cells might be considered by the thymus as self-peptides, and T cells specific for these peptides might be deleted (negatively selected). We demonstrated in four baboons infected with baboon cytomegalovirus and baboon lymphocryptovirus (Epstein-Barr virus-like virus) that after autologous transplantation of yellow fluorescent protein (YFP)-marked hematopoietic cells, YFP+ CD4 T cells against these viruses were generated de novo. Thus the thymus generates CD4 T cells against not only pathogens absent from the host but also pathogens present in the host. This finding provides a strong rationale to improve thymopoiesis in hematopoietic cell transplant recipients." @default.
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- W2030805520 date "2005-02-01" @default.
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- W2030805520 title "De novo generation of CD4 T cells against viruses present in the host during immune reconstitution" @default.
- W2030805520 doi "https://doi.org/10.1016/j.bbmt.2004.12.160" @default.
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