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• W2030809600 abstract "Chronic use of psychostimulants induces enduringly increased responsiveness to a subsequent psychostimulant injection and sensitivity to drug-associated cues, contributing to drug craving and relapse. Neurotensin (NT), a neuropeptide functionally linked to dopaminergic neurons, was suggested to participate in these phenomena. We and others have reported that SR 48692, an NT receptor antagonist, given in pre- or cotreatments with cocaine or amphetamine, alters some behavioral effects of these drugs in rats. However, its efficacy when applied following repeated cocaine administration remains unknown. We, therefore, evaluated the ability of SR 48692, administered after a cocaine regimen, to interfere with the expression of locomotor sensitization and conditioned place preference (CPP) in rats. We demonstrated that the expression of locomotor sensitization, induced by four cocaine injections (15 mg/kg, i.p.) every other day and a cocaine challenge 1 week later, was attenuated by a subsequent 2-week daily administration of SR 48692 (1 mg/kg, i.p.). Furthermore, the expression of cocaine-induced CPP was suppressed by a 10-day SR 48692 treatment started after the conditioning period (four 15 mg/kg cocaine injections every other day). Taken together, our data show that a chronic SR 48692 treatment given after a cocaine regimen partly reverses the expression of locomotor sensitization and CPP in the rat, suggesting that NT participates in the maintenance of these behaviors. Our results support the hypothesis that targeting neuromodulatory systems, such as the NT systems may offer new strategies in the treatment of drug addiction." @default.
• W2030809600 created "2016-06-24" @default.
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• W2030809600 date "2007-03-14" @default.
• W2030809600 modified "2023-10-11" @default.
• W2030809600 title "Neurotensin Receptor Antagonist Administered during Cocaine Withdrawal Decreases Locomotor Sensitization and Conditioned Place Preference" @default.
• W2030809600 cites W1536914579 @default.
• W2030809600 cites W1556555813 @default.
• W2030809600 cites W1593759117 @default.
• W2030809600 cites W1607957872 @default.
• W2030809600 cites W1743432501 @default.
• W2030809600 cites W1939457774 @default.
• W2030809600 cites W1964263145 @default.
• W2030809600 cites W1967089266 @default.
• W2030809600 cites W1970238016 @default.
• W2030809600 cites W1970249278 @default.
• W2030809600 cites W1970425577 @default.
• W2030809600 cites W1971195953 @default.
• W2030809600 cites W1971609010 @default.
• W2030809600 cites W1977967661 @default.
• W2030809600 cites W1981514537 @default.
• W2030809600 cites W1982647806 @default.
• W2030809600 cites W1983869923 @default.
• W2030809600 cites W1987722879 @default.
• W2030809600 cites W1990005995 @default.
• W2030809600 cites W1990413322 @default.
• W2030809600 cites W1991007482 @default.
• W2030809600 cites W1996773576 @default.
• W2030809600 cites W1997992794 @default.
• W2030809600 cites W1998033984 @default.
• W2030809600 cites W2001149576 @default.
• W2030809600 cites W2006369404 @default.
• W2030809600 cites W2007604257 @default.
• W2030809600 cites W2009243814 @default.
• W2030809600 cites W2010533815 @default.
• W2030809600 cites W2013214129 @default.
• W2030809600 cites W2013531686 @default.
• W2030809600 cites W2013940388 @default.
• W2030809600 cites W2014061405 @default.
• W2030809600 cites W2014095338 @default.
• W2030809600 cites W2018303551 @default.
• W2030809600 cites W2018482621 @default.
• W2030809600 cites W2022133574 @default.
• W2030809600 cites W2022406556 @default.
• W2030809600 cites W2022628553 @default.
• W2030809600 cites W2022992863 @default.
• W2030809600 cites W2028424000 @default.
• W2030809600 cites W2031011785 @default.
• W2030809600 cites W2036218676 @default.
• W2030809600 cites W2036354160 @default.
• W2030809600 cites W2037307403 @default.
• W2030809600 cites W2041265674 @default.
• W2030809600 cites W2042464546 @default.
• W2030809600 cites W2042624443 @default.
• W2030809600 cites W2042965074 @default.
• W2030809600 cites W2054400557 @default.
• W2030809600 cites W2055319462 @default.
• W2030809600 cites W2056863048 @default.
• W2030809600 cites W2058562215 @default.
• W2030809600 cites W2061629598 @default.
• W2030809600 cites W2068406343 @default.
• W2030809600 cites W2068735847 @default.
• W2030809600 cites W2071658582 @default.
• W2030809600 cites W2073384618 @default.
• W2030809600 cites W2078154797 @default.
• W2030809600 cites W2083466345 @default.
• W2030809600 cites W2085680303 @default.
• W2030809600 cites W2089796125 @default.
• W2030809600 cites W2097300084 @default.
• W2030809600 cites W2103481021 @default.
• W2030809600 cites W2106156723 @default.
• W2030809600 cites W2106862702 @default.
• W2030809600 cites W2108917606 @default.
• W2030809600 cites W2111774737 @default.
• W2030809600 cites W2119784019 @default.
• W2030809600 cites W2128873745 @default.
• W2030809600 cites W2130715237 @default.
• W2030809600 cites W2132592929 @default.
• W2030809600 cites W2146022709 @default.
• W2030809600 cites W2165034198 @default.
• W2030809600 cites W4231368206 @default.
• W2030809600 cites W4247649320 @default.
• W2030809600 cites W71275267 @default.
• W2030809600 cites W2046979162 @default.
• W2030809600 doi "https://doi.org/10.1038/sj.npp.1301382" @default.
• W2030809600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2992550" @default.
• W2030809600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17356568" @default.
• W2030809600 hasPublicationYear "2007" @default.
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