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- W2030828553 abstract "Intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance in liver nuclei of three tyrosine phosphorylated proteins (84, 91, and 92 kilodaltons) within minutes after administration of EGF. Administration of interferon-γ (IFN-γ) resulted in the appearance in liver nuclei of two tyrosine phosphorylated proteins (84 and 91 kilodaltons). The 84- and 91-kilodalton proteins detected after either EGF or IFN-γ administration were identified as the IFN-γ activation factors (GAF). Furthermore, gel shift analysis revealed that these GAF proteins, detected after either EGF or IFN-γ administration, specifically bound to the sis-inducible element of the c-fos promoter. Thus, GAF proteins participate in nuclear signaling in both IFN-γ and EGF pathways." @default.
- W2030828553 created "2016-06-24" @default.
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- W2030828553 date "1993-09-24" @default.
- W2030828553 modified "2023-10-15" @default.
- W2030828553 title "Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei" @default.
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- W2030828553 doi "https://doi.org/10.1126/science.8378774" @default.
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