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- W2030835242 abstract "See article by Stawowy et al. (pages 50–59) in this issue .Angiotensin II (Ang II) is an essential regulator of homeostasis and response to pathological stimuli in the cardiovascular system. In addition to its short- and long-term hemodynamic effects, Ang II plays an important role in cardiovascular remodeling in hypertension, myocardial infarction and chronic heart failure. In recent years, great efforts have been made to identify specific intracellular signaling pathways that are activated in cardiac myocytes and fibroblasts during the process of ventricular remodeling. Despite significant progress, the precise role of individual pathways and their relevance in cardiac myocytes and fibroblasts are only partly understood.In this issue of Cardiovascular Research , Stawowy et al. [1] describe a novel signaling pathway for Ang II-mediated adhesion of cardiac fibroblasts to extracellular matrix. This study convincingly demonstrates that a specific protein kinase C subtype, PKCe, is essential for inside–out signaling of β1-integrin-activated adhesion of cardiac fibroblasts to the extracellular matrix.Protein kinase C may be regulated by a number of different stimuli. All G protein-coupled receptors that activate Gαq/11 proteins, e.g. AT1 receptors via phospholipase Cβ, which releases diacylglycerol and inositol trisphosphate, initiate PKC activation (Fig. 1). Other stimuli that are associated with PKC activation, e.g. ischemia/reperfusion or pressure overload, are less … *Tel.: +49 761 203 5313; fax: +49 761 203 5318. Email address: lutz.hein{at}pharmakol.uni-freiburg.de" @default.
- W2030835242 created "2016-06-24" @default.
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- W2030835242 date "2005-07-01" @default.
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- W2030835242 title "Angiotensin II and cell-matrix adhesion: PKCɛ is essential" @default.
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- W2030835242 doi "https://doi.org/10.1016/j.cardiores.2005.05.008" @default.
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