Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030838406> ?p ?o ?g. }
- W2030838406 endingPage "356" @default.
- W2030838406 startingPage "345" @default.
- W2030838406 abstract "Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells. However, the effect of CTGF on migration activity in human chondrosarcoma cells is mostly unknown. Here we found that CTGF increased the migration and expression of matrix metalloproteinase (MMP)-13 in human chondrosarcoma cells (JJ012 cells). RGD peptide, alphavbeta3 monoclonal antibody (mAb) and MAPK kinase (MEK) inhibitors (PD98059 and U0126) but not RAD peptide inhibited the CTGF-induced increase of the migration and MMP-13 up-regulation of chondrosarcoma cells. CTGF stimulation increased the phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). In addition, treatment of JJ012 cells with NF-kappaB inhibitor (PDTC) or IkappaB protease inhibitor (TPCK) inhibited CTGF-induced cell migration and MMP-13 up-regulation. Stimulation of JJ012 cells with CTGF also induced IkappaB kinase alpha/beta (IKK alpha/beta) phosphorylation, IkappaBalpha phosphorylation, p65 Ser(536) phosphorylation, and kappaB-luciferase activity. The CTGF-mediated increases in kappaB-luciferase activities were inhibited by RGD, PD98059, U0126 or FAK, and ERK2 mutant. Taken together, our results indicated that CTGF enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3 integrin, FAK, ERK, and NF-kappaB signal transduction pathway." @default.
- W2030838406 created "2016-06-24" @default.
- W2030838406 creator A5020065067 @default.
- W2030838406 creator A5024344102 @default.
- W2030838406 creator A5026324108 @default.
- W2030838406 creator A5058015003 @default.
- W2030838406 creator A5066790675 @default.
- W2030838406 creator A5076096342 @default.
- W2030838406 creator A5085507861 @default.
- W2030838406 creator A5090381530 @default.
- W2030838406 date "2009-03-19" @default.
- W2030838406 modified "2023-10-10" @default.
- W2030838406 title "CTGF enhances migration and MMP-13 up-regulation via αvβ3 integrin, FAK, ERK, and NF-κB-dependent pathway in human chondrosarcoma cells" @default.
- W2030838406 cites W1554947160 @default.
- W2030838406 cites W1576773659 @default.
- W2030838406 cites W1607041879 @default.
- W2030838406 cites W1854585025 @default.
- W2030838406 cites W1900570432 @default.
- W2030838406 cites W1965072143 @default.
- W2030838406 cites W1968790357 @default.
- W2030838406 cites W1983426119 @default.
- W2030838406 cites W1990985871 @default.
- W2030838406 cites W1999512677 @default.
- W2030838406 cites W2003500892 @default.
- W2030838406 cites W2003982318 @default.
- W2030838406 cites W2032346241 @default.
- W2030838406 cites W2036285327 @default.
- W2030838406 cites W2044719350 @default.
- W2030838406 cites W2053865773 @default.
- W2030838406 cites W2063295519 @default.
- W2030838406 cites W2086511139 @default.
- W2030838406 cites W2090644462 @default.
- W2030838406 cites W2104756805 @default.
- W2030838406 cites W2111380872 @default.
- W2030838406 cites W2112417973 @default.
- W2030838406 cites W2116426583 @default.
- W2030838406 cites W2143647993 @default.
- W2030838406 cites W2144474454 @default.
- W2030838406 cites W2157252649 @default.
- W2030838406 cites W2157942810 @default.
- W2030838406 cites W2171894706 @default.
- W2030838406 cites W4213141530 @default.
- W2030838406 cites W4255941290 @default.
- W2030838406 cites W4376848667 @default.
- W2030838406 doi "https://doi.org/10.1002/jcb.22132" @default.
- W2030838406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19301259" @default.
- W2030838406 hasPublicationYear "2009" @default.
- W2030838406 type Work @default.
- W2030838406 sameAs 2030838406 @default.
- W2030838406 citedByCount "80" @default.
- W2030838406 countsByYear W20308384062012 @default.
- W2030838406 countsByYear W20308384062013 @default.
- W2030838406 countsByYear W20308384062014 @default.
- W2030838406 countsByYear W20308384062015 @default.
- W2030838406 countsByYear W20308384062016 @default.
- W2030838406 countsByYear W20308384062017 @default.
- W2030838406 countsByYear W20308384062018 @default.
- W2030838406 countsByYear W20308384062019 @default.
- W2030838406 countsByYear W20308384062020 @default.
- W2030838406 countsByYear W20308384062021 @default.
- W2030838406 countsByYear W20308384062022 @default.
- W2030838406 countsByYear W20308384062023 @default.
- W2030838406 crossrefType "journal-article" @default.
- W2030838406 hasAuthorship W2030838406A5020065067 @default.
- W2030838406 hasAuthorship W2030838406A5024344102 @default.
- W2030838406 hasAuthorship W2030838406A5026324108 @default.
- W2030838406 hasAuthorship W2030838406A5058015003 @default.
- W2030838406 hasAuthorship W2030838406A5066790675 @default.
- W2030838406 hasAuthorship W2030838406A5076096342 @default.
- W2030838406 hasAuthorship W2030838406A5085507861 @default.
- W2030838406 hasAuthorship W2030838406A5090381530 @default.
- W2030838406 hasConcept C11960822 @default.
- W2030838406 hasConcept C137738243 @default.
- W2030838406 hasConcept C1491633281 @default.
- W2030838406 hasConcept C151166631 @default.
- W2030838406 hasConcept C153911025 @default.
- W2030838406 hasConcept C170493617 @default.
- W2030838406 hasConcept C184235292 @default.
- W2030838406 hasConcept C185592680 @default.
- W2030838406 hasConcept C189165786 @default.
- W2030838406 hasConcept C195687474 @default.
- W2030838406 hasConcept C2775960820 @default.
- W2030838406 hasConcept C2780631158 @default.
- W2030838406 hasConcept C2781249067 @default.
- W2030838406 hasConcept C502942594 @default.
- W2030838406 hasConcept C55493867 @default.
- W2030838406 hasConcept C57074206 @default.
- W2030838406 hasConcept C62478195 @default.
- W2030838406 hasConcept C86492073 @default.
- W2030838406 hasConcept C86803240 @default.
- W2030838406 hasConcept C95444343 @default.
- W2030838406 hasConceptScore W2030838406C11960822 @default.
- W2030838406 hasConceptScore W2030838406C137738243 @default.
- W2030838406 hasConceptScore W2030838406C1491633281 @default.
- W2030838406 hasConceptScore W2030838406C151166631 @default.
- W2030838406 hasConceptScore W2030838406C153911025 @default.
- W2030838406 hasConceptScore W2030838406C170493617 @default.
- W2030838406 hasConceptScore W2030838406C184235292 @default.