Matches in SemOpenAlex for { <https://semopenalex.org/work/W203086843> ?p ?o ?g. }
- W203086843 endingPage "257" @default.
- W203086843 startingPage "209" @default.
- W203086843 abstract "Platelets circulate in the blood stream in a quiescent state but undergo explosive activation at sites of damage to the blood vessel wall, leading to formation of a haemostatic plug and cessation of bleeding. The quiescent state of the platelet is maintained in part by the inhibitory action of constitutively released nitric oxide from endothelial cells lining the blood vessels. Activation is brought about by contact with extracellular matrix proteins exposed at the site of tissue damage, notably collagen fibres, and is reinforced by release and generation of a large number of substances such as thrombin and thromboxanes. The remarkable number and diversity of these agents facilitates rapid formation of the platelet aggregate leading to arrest of bleeding. Activation of platelets within intact blood vessels, however, can lead to vascular occlusion with subsequent ischaemic tissue damage. In the most severe cases, this leads to myocardial infarction or stroke, two of the major causes of death in the Western world. The platelet, therefore, is a major target for therapeutic intervention in the prevention of thrombotic disease.KeywordsPlatelet ActivationTyrosine PhosphorylationAdenylyl CyclaseHuman PlateletPlatelet SurfaceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W203086843 created "2016-06-24" @default.
- W203086843 creator A5045627202 @default.
- W203086843 creator A5075042066 @default.
- W203086843 creator A5077850040 @default.
- W203086843 date "1999-01-01" @default.
- W203086843 modified "2023-09-27" @default.
- W203086843 title "Platelet Membrane Receptors and Signalling Pathways: New Therapeutic Targets" @default.
- W203086843 cites W111332543 @default.
- W203086843 cites W112886495 @default.
- W203086843 cites W134382889 @default.
- W203086843 cites W138570360 @default.
- W203086843 cites W1498265361 @default.
- W203086843 cites W1567813092 @default.
- W203086843 cites W1774746154 @default.
- W203086843 cites W180211874 @default.
- W203086843 cites W1880336884 @default.
- W203086843 cites W1898094335 @default.
- W203086843 cites W1905974175 @default.
- W203086843 cites W19388958 @default.
- W203086843 cites W1964456661 @default.
- W203086843 cites W1968120489 @default.
- W203086843 cites W1972760976 @default.
- W203086843 cites W1974052300 @default.
- W203086843 cites W1980947524 @default.
- W203086843 cites W1982186905 @default.
- W203086843 cites W1986003353 @default.
- W203086843 cites W1990500910 @default.
- W203086843 cites W1992628345 @default.
- W203086843 cites W1993859463 @default.
- W203086843 cites W1996526473 @default.
- W203086843 cites W2000808409 @default.
- W203086843 cites W2001138501 @default.
- W203086843 cites W2004756723 @default.
- W203086843 cites W2007781471 @default.
- W203086843 cites W2016969337 @default.
- W203086843 cites W2017888388 @default.
- W203086843 cites W2021156311 @default.
- W203086843 cites W2021284850 @default.
- W203086843 cites W2021907259 @default.
- W203086843 cites W2025818505 @default.
- W203086843 cites W2026217553 @default.
- W203086843 cites W2026458612 @default.
- W203086843 cites W2027875344 @default.
- W203086843 cites W2029231027 @default.
- W203086843 cites W2030014173 @default.
- W203086843 cites W2032425418 @default.
- W203086843 cites W2032822608 @default.
- W203086843 cites W2033164168 @default.
- W203086843 cites W2034419085 @default.
- W203086843 cites W2035816283 @default.
- W203086843 cites W2036842366 @default.
- W203086843 cites W2037583192 @default.
- W203086843 cites W2038816853 @default.
- W203086843 cites W2038993690 @default.
- W203086843 cites W2043526402 @default.
- W203086843 cites W2043823402 @default.
- W203086843 cites W2043882835 @default.
- W203086843 cites W2049562267 @default.
- W203086843 cites W2049585077 @default.
- W203086843 cites W2050562067 @default.
- W203086843 cites W2056945159 @default.
- W203086843 cites W2057372364 @default.
- W203086843 cites W2058252812 @default.
- W203086843 cites W2058839845 @default.
- W203086843 cites W2059121005 @default.
- W203086843 cites W2059428160 @default.
- W203086843 cites W2060482756 @default.
- W203086843 cites W2062613174 @default.
- W203086843 cites W2066826486 @default.
- W203086843 cites W2072027589 @default.
- W203086843 cites W2072948376 @default.
- W203086843 cites W2075013504 @default.
- W203086843 cites W2079349364 @default.
- W203086843 cites W2079695285 @default.
- W203086843 cites W2079799412 @default.
- W203086843 cites W2080986144 @default.
- W203086843 cites W2081753893 @default.
- W203086843 cites W2085083847 @default.
- W203086843 cites W2088020253 @default.
- W203086843 cites W2088438515 @default.
- W203086843 cites W209067059 @default.
- W203086843 cites W2093175816 @default.
- W203086843 cites W2111688914 @default.
- W203086843 cites W2124990648 @default.
- W203086843 cites W2126058021 @default.
- W203086843 cites W2140010130 @default.
- W203086843 cites W2144001627 @default.
- W203086843 cites W2144935474 @default.
- W203086843 cites W2146388445 @default.
- W203086843 cites W2151477904 @default.
- W203086843 cites W2160311718 @default.
- W203086843 cites W2161503938 @default.
- W203086843 cites W2165453706 @default.
- W203086843 cites W2169030528 @default.
- W203086843 cites W2169429927 @default.
- W203086843 cites W2189094602 @default.
- W203086843 cites W2215348743 @default.