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• W2030883104 abstract "Increasing concentrations of young or old mouse adherent peritoneal exudate cells (Y-PEC, O-PEC) have a different effect on the concanavalin A-induced proliferation of young (< 4 months) or old (>10 months) syngeneic mouse spleen cells (Y-SC, O-SC). Whereas the addition of NZB Y-SC to cultures of syngeneic Y-PEC resulted in a progressive suppression of the mitogenic response of Y-SC, the presence of similar concentrations of NZB O-PEC resulted in augmentation of that response which was significant (P < 0.05) at 20% PEC concentration. The NZB O-PEC also had a less suppressive effect on their O-SC. Similar but not as significant results (P < 0.1) were observed with cultures of O-PEC and Y-SC from BALB/c mice. In contrast, Y-PEC and O-PEC from seven other mouse strains substantially reduced the mitogenic response of both syngeneic Y-SC and O-SC. These observations could not be explained by differences in prostaglandin E2 synthesis by the PEC or by crowded culture conditions. Our results suggest that either the population or the function of NZB peritoneal macrophages changes as the mouse ages and develops autoimmune disease." @default.
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• W2030883104 date "1982-09-01" @default.
• W2030883104 modified "2023-10-14" @default.
• W2030883104 title "Unusual characteristics of peritoneal macrophages from aged autoimmune-prone mice" @default.
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• W2030883104 doi "https://doi.org/10.1016/0008-8749(82)90280-5" @default.
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