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- W2030886502 abstract "We have evaluated the analgesic effectiveness of dextromoramide and racemoramide (a racemic mixture of dextromoramide and its optical isomer, levomoramide) in normal subjects, in patients with chronic pain, and in patients with acute postoperative pain. In addition, we have attempted to determine the addictive liability of the drugs in question. Both dextromoramide and racemoramide are effective analgesics when given either orally or subcutaneously. Dextromoramide is approximately twice as potent as racemoramide, per os. In normal subjects 10 mg. of dextromoramide per os is as effective as 100 mg. of meperidine per os or 10 mg. of methadone per os in elevating experimental pain thresholds. The optimum oral dosage of dextromoramide is 5 to 10 mg.; of racemoramide 10 to 20 mg. The average duration of analgesia produced by either drug ranges from 3.4 ± 0.7 to 4.8 ± 1.3 hours. Occasionally, analgesia of 8 hours' duration has been observed when dextromoramide was administered subcutaneously for chronic pain. Side effects attending the use of dextromoramide and racemoramide are similar to those attending the use of other potent analgesics. In patients with chronic pain, tolerance to side effects seems to develop rapidly. Although dextromoramide does have potential addictive liability, primary addiction was not observed during its prolonged administration to 7 patients. Secondary addiction has been observed in one patient receiving racemoramide." @default.
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- W2030886502 date "1959-07-01" @default.
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- W2030886502 title "An evaluation of two new analgesics (dextromoramide and racemoramide) in healthy subjects and in patients with chronic pain" @default.
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- W2030886502 doi "https://doi.org/10.1016/0021-9681(59)90018-9" @default.
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