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• W2030887950 abstract "RationaleRhinovirus (RV) wheezing illness in early life is a risk factor for subsequent childhood asthma. Whether the species of rhinovirus causing the wheezing illness differentially affects asthma risk is unknown. We hypothesized that RV-C wheezing would be the best predictor of asthma development.MethodsChildren participating in a high-risk birth cohort (Childhood Origins of ASThma) were followed prospectively to determine wheezing illnesses with specific RV species in the first year of life. A total of 259 children were followed at year 6, 238 at year 8, and 217 at year 11. Asthma was defined by physician diagnosis, the use of SABA, daily ICS, step-up therapy and/or oral corticosteroids. Nasal samples were collected during wheezing illnesses and analyzed for respiratory viruses using multiplex PCR, partial sequencing for RV typing.ResultsChildren who wheezed with RV-C in the first year of life had significantly higher rates of asthma at age 6 [OR 3.5 (1.3, 9.7)], but not at ages 8 [OR 1.8 (0.6, 5.2)] or 11 [OR 2.6 (0.9, 7.3)]. Wheezing with RV-A was not associated with asthma at year 6 [OR 1.3 (0.6, 3.1)], year 8 [OR 2.3 (1.0, 5.4)] or year 11 [OR 1.7 (0.7, 4.1)]. There were no wheezing episodes associated with RV-B infections.ConclusionsThis longitudinal analysis suggests that wheezing with RV-C in the first year of life is an indicator of increased risk for the subsequent development of asthma. Additional studies are needed to confirm this observation. RationaleRhinovirus (RV) wheezing illness in early life is a risk factor for subsequent childhood asthma. Whether the species of rhinovirus causing the wheezing illness differentially affects asthma risk is unknown. We hypothesized that RV-C wheezing would be the best predictor of asthma development. Rhinovirus (RV) wheezing illness in early life is a risk factor for subsequent childhood asthma. Whether the species of rhinovirus causing the wheezing illness differentially affects asthma risk is unknown. We hypothesized that RV-C wheezing would be the best predictor of asthma development. MethodsChildren participating in a high-risk birth cohort (Childhood Origins of ASThma) were followed prospectively to determine wheezing illnesses with specific RV species in the first year of life. A total of 259 children were followed at year 6, 238 at year 8, and 217 at year 11. Asthma was defined by physician diagnosis, the use of SABA, daily ICS, step-up therapy and/or oral corticosteroids. Nasal samples were collected during wheezing illnesses and analyzed for respiratory viruses using multiplex PCR, partial sequencing for RV typing. Children participating in a high-risk birth cohort (Childhood Origins of ASThma) were followed prospectively to determine wheezing illnesses with specific RV species in the first year of life. A total of 259 children were followed at year 6, 238 at year 8, and 217 at year 11. Asthma was defined by physician diagnosis, the use of SABA, daily ICS, step-up therapy and/or oral corticosteroids. Nasal samples were collected during wheezing illnesses and analyzed for respiratory viruses using multiplex PCR, partial sequencing for RV typing. ResultsChildren who wheezed with RV-C in the first year of life had significantly higher rates of asthma at age 6 [OR 3.5 (1.3, 9.7)], but not at ages 8 [OR 1.8 (0.6, 5.2)] or 11 [OR 2.6 (0.9, 7.3)]. Wheezing with RV-A was not associated with asthma at year 6 [OR 1.3 (0.6, 3.1)], year 8 [OR 2.3 (1.0, 5.4)] or year 11 [OR 1.7 (0.7, 4.1)]. There were no wheezing episodes associated with RV-B infections. Children who wheezed with RV-C in the first year of life had significantly higher rates of asthma at age 6 [OR 3.5 (1.3, 9.7)], but not at ages 8 [OR 1.8 (0.6, 5.2)] or 11 [OR 2.6 (0.9, 7.3)]. Wheezing with RV-A was not associated with asthma at year 6 [OR 1.3 (0.6, 3.1)], year 8 [OR 2.3 (1.0, 5.4)] or year 11 [OR 1.7 (0.7, 4.1)]. There were no wheezing episodes associated with RV-B infections. ConclusionsThis longitudinal analysis suggests that wheezing with RV-C in the first year of life is an indicator of increased risk for the subsequent development of asthma. Additional studies are needed to confirm this observation. This longitudinal analysis suggests that wheezing with RV-C in the first year of life is an indicator of increased risk for the subsequent development of asthma. Additional studies are needed to confirm this observation." @default.
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• W2030887950 date "2015-02-01" @default.
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• W2030887950 title "Rhinovirus A and C Wheezing Illness in Infancy and the Development of Asthma" @default.
• W2030887950 doi "https://doi.org/10.1016/j.jaci.2014.12.1295" @default.
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