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• W2030888955 abstract "The short-term metabolic effects of testosterone treatment on circulating levels of 1,25–dihydroxyvitamin D and insulin-like growth factor-I (IGF-I) were studied in 13 hypogonadal men. The study group included 11 men with Klinefelter's syndrome, with varying degree of androgen deficiency, and two men with secondary hypogonadism. Pretreatment levels of 1,25–dihydroxyvitamin D, vitamin D-binding protein and IGF-binding protein-I were all within the normal range. The levels of IGF-I were lower than normal in 5/11 of the Klinefelter patients and in one patient with GH-deficiency. Testosterone treatment increased circulating total 1,25–dihydroxyvitamin D significantly from 75 ± 4 pmol l-1 (mean ± SEM) to 86 ± 4 (P<0.01) and the free 1,25–dihydroxyvitamin D-index from 1.95 ± 0.11 to 2.39 ± 0.12 (P<0.01). Serum levels of IGF-I increased from 117 ± 22 ug/l to 143 ± 23 (P<0.01) during androgen treatment. No significant effects on levels of IGF-binding protein-I were seen. It is concluded that androgen therapy increases the availability of 1,25–dihydroxyvitamin D and the level of IGF-I, which may be important links in the action of testosterone." @default.
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• W2030888955 date "1992-04-01" @default.
• W2030888955 modified "2023-09-29" @default.
• W2030888955 title "Testosterone increases serum 1,25–dihydroxyvitamin D and insulin-like growth factor-I in hypogonadal men" @default.
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• W2030888955 doi "https://doi.org/10.1111/j.1365-2605.1992.tb01118.x" @default.
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