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• W2030890417 abstract "The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C 4 when exposed to the Ca 2+ ionophore A23187, reaching maximal stimulation at 5.0 μM. This response was inhibited by the 5-lipoxygenase activating protein antagonist MK-886 (0.1 μM), nominally Ca 2+ and Mg 2+ -free incubation media and by activation of protein kinase C via phorbol 12-myristate 13-acetate (50 nM). These findings establish a model system for investigating LTC 4 profiles contingent with innate peritoneal eosinophilia and are consistent with the hypothesis that cellular LTC 4 biosynthesis is phosphoregulated." @default.
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• W2030890417 date "1996-01-01" @default.
• W2030890417 modified "2023-10-11" @default.
• W2030890417 title "Leukotriene C4biosynthesis in isolated August rat peritoneal leukocytes" @default.
• W2030890417 doi "https://doi.org/10.1155/s0962935196000610" @default.
• W2030890417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2365822" @default.
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