FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030893345> ?p ?o ?g. }

• W2030893345 endingPage "452" @default.
• W2030893345 startingPage "443" @default.
• W2030893345 abstract "Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system. BmK I, a site-3 sodium channel-specific toxin from scorpion Buthus martensi Karsch, induces pain behaviors in rats. However, the subtypes of VGSCs targeted by BmK I were not entirely clear. We therefore investigated the effects of BmK I on the current amplitude, gating and kinetic properties of Nav1.8, which is associated with neuronal hyperexcitability in DRG neurons. It was found that BmK I dose-dependently increased Nav1.8 current in small-sized (<25 μm) acutely dissociated DRG neurons, which correlated with its inhibition on both fast and slow inactivation. Moreover, voltage-dependent activation and steady-state inactivation curves of Nav1.8 were shifted in a hyperpolarized direction. Thus, BmK I reduced the threshold of neuronal excitability and increased action potential firing in DRG neurons. In conclusion, our data clearly demonstrated that BmK I modulated Nav1.8 remarkably, suggesting BmK I as a valuable probe for studying Nav1.8. And Nav1.8 is an important target related to BmK I-evoked pain." @default.
• W2030893345 created "2016-06-24" @default.
• W2030893345 creator A5039401177 @default.
• W2030893345 creator A5046775442 @default.
• W2030893345 creator A5056487554 @default.
• W2030893345 creator A5067969291 @default.
• W2030893345 creator A5073088792 @default.
• W2030893345 creator A5076523459 @default.
• W2030893345 creator A5077430901 @default.
• W2030893345 creator A5078861367 @default.
• W2030893345 date "2015-04-24" @default.
• W2030893345 modified "2023-10-14" @default.
• W2030893345 title "Scorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats" @default.
• W2030893345 cites W1851624642 @default.
• W2030893345 cites W1966300055 @default.
• W2030893345 cites W1968375456 @default.
• W2030893345 cites W1975085840 @default.
• W2030893345 cites W1977073662 @default.
• W2030893345 cites W1978939719 @default.
• W2030893345 cites W1983434348 @default.
• W2030893345 cites W1988609075 @default.
• W2030893345 cites W1994735513 @default.
• W2030893345 cites W2003020426 @default.
• W2030893345 cites W2007723329 @default.
• W2030893345 cites W2009367742 @default.
• W2030893345 cites W2013514756 @default.
• W2030893345 cites W2018333855 @default.
• W2030893345 cites W2022339065 @default.
• W2030893345 cites W2029217560 @default.
• W2030893345 cites W2059635921 @default.
• W2030893345 cites W2060300968 @default.
• W2030893345 cites W2064189343 @default.
• W2030893345 cites W2068707948 @default.
• W2030893345 cites W2083067296 @default.
• W2030893345 cites W2085790923 @default.
• W2030893345 cites W2087454739 @default.
• W2030893345 cites W2099814157 @default.
• W2030893345 cites W2101573249 @default.
• W2030893345 cites W2138809708 @default.
• W2030893345 cites W2156255142 @default.
• W2030893345 cites W40340874 @default.
• W2030893345 doi "https://doi.org/10.1007/s13238-015-0154-4" @default.
• W2030893345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4444811" @default.
• W2030893345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25903152" @default.
• W2030893345 hasPublicationYear "2015" @default.
• W2030893345 type Work @default.
• W2030893345 sameAs 2030893345 @default.
• W2030893345 citedByCount "11" @default.
• W2030893345 countsByYear W20308933452016 @default.
• W2030893345 countsByYear W20308933452017 @default.
• W2030893345 countsByYear W20308933452019 @default.
• W2030893345 countsByYear W20308933452021 @default.
• W2030893345 countsByYear W20308933452022 @default.
• W2030893345 countsByYear W20308933452023 @default.
• W2030893345 crossrefType "journal-article" @default.
• W2030893345 hasAuthorship W2030893345A5039401177 @default.
• W2030893345 hasAuthorship W2030893345A5046775442 @default.
• W2030893345 hasAuthorship W2030893345A5056487554 @default.
• W2030893345 hasAuthorship W2030893345A5067969291 @default.
• W2030893345 hasAuthorship W2030893345A5073088792 @default.
• W2030893345 hasAuthorship W2030893345A5076523459 @default.
• W2030893345 hasAuthorship W2030893345A5077430901 @default.
• W2030893345 hasAuthorship W2030893345A5078861367 @default.
• W2030893345 hasBestOaLocation W20308933451 @default.
• W2030893345 hasConcept C169760540 @default.
• W2030893345 hasConcept C178790620 @default.
• W2030893345 hasConcept C185592680 @default.
• W2030893345 hasConcept C194544171 @default.
• W2030893345 hasConcept C2775908076 @default.
• W2030893345 hasConcept C2776676993 @default.
• W2030893345 hasConcept C2777589315 @default.
• W2030893345 hasConcept C2777884321 @default.
• W2030893345 hasConcept C2779448229 @default.
• W2030893345 hasConcept C2779705967 @default.
• W2030893345 hasConcept C50952357 @default.
• W2030893345 hasConcept C537181965 @default.
• W2030893345 hasConcept C55493867 @default.
• W2030893345 hasConcept C71924100 @default.
• W2030893345 hasConcept C86803240 @default.
• W2030893345 hasConcept C94487597 @default.
• W2030893345 hasConceptScore W2030893345C169760540 @default.
• W2030893345 hasConceptScore W2030893345C178790620 @default.
• W2030893345 hasConceptScore W2030893345C185592680 @default.
• W2030893345 hasConceptScore W2030893345C194544171 @default.
• W2030893345 hasConceptScore W2030893345C2775908076 @default.
• W2030893345 hasConceptScore W2030893345C2776676993 @default.
• W2030893345 hasConceptScore W2030893345C2777589315 @default.
• W2030893345 hasConceptScore W2030893345C2777884321 @default.
• W2030893345 hasConceptScore W2030893345C2779448229 @default.
• W2030893345 hasConceptScore W2030893345C2779705967 @default.
• W2030893345 hasConceptScore W2030893345C50952357 @default.
• W2030893345 hasConceptScore W2030893345C537181965 @default.
• W2030893345 hasConceptScore W2030893345C55493867 @default.
• W2030893345 hasConceptScore W2030893345C71924100 @default.
• W2030893345 hasConceptScore W2030893345C86803240 @default.
• W2030893345 hasConceptScore W2030893345C94487597 @default.
• W2030893345 hasIssue "6" @default.
• W2030893345 hasLocation W20308933451 @default.

• next