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- W2030893642 abstract "Article on page 200 Defective Dendritic Cell Generation from Monocytes is a Potential Reason for Poor Therapeutic Efficacy of Interferon α2b (IFNα2b) in Cervical Cancer Roy S, Goswami S, Bose A, Goswami KK, Sarkar K, Chakraborty K, Chakraborty T, Pal S, Haldar A, Basu P, Biswas J, Baral R Interferons are a class of proinflammatory cytokines with important immunologic functions, especially in regard to host defense against viral infections. Interferons are also unique cytokines in their ability to be produced by and to activate numerous cell types, of both hematopoietic and stromal origin. For example, interferons stimulate the activation of immune cells through the upregulation of major histocompatibility complex (MHC) molecules, promoting antigen presentation and lymphocyte activation. 1 Luft T. Pang K.C. Thomas E. et al. Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol. 1998; 161: 1947-1953 PubMed Google Scholar In addition, interferon has potent antiproliferative/proapoptotic effects, and it can signal many cell types to degrade messenger RNA and limit protein synthesis, in an attempt to limit viral replication in infected (or potentially infected) cells. 2 Grandvaux N. tenOever B.R. Servant M.J. Hiscott J. The interferon antiviral response: from viral invasion to evasion. Curr Opin Infect Dis. 2002; 15: 259-267 Crossref PubMed Scopus (173) Google Scholar Article on page 200 Defective Dendritic Cell Generation from Monocytes is a Potential Reason for Poor Therapeutic Efficacy of Interferon α2b (IFNα2b) in Cervical Cancer Roy S, Goswami S, Bose A, Goswami KK, Sarkar K, Chakraborty K, Chakraborty T, Pal S, Haldar A, Basu P, Biswas J, Baral R" @default.
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- W2030893642 date "2011-10-01" @default.
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- W2030893642 title "Monocytes to functional dendritic cells is often a bridge too far for cancer therapy" @default.
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- W2030893642 doi "https://doi.org/10.1016/j.trsl.2011.04.002" @default.
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