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• W2030896727 abstract "We previously reported that dopamine (DA) inhibited the release of human placental lactogen (hPL) from human placental cells. We also demonstrated the presence of D2-dopamine receptors in membrane preparations of human term placenta. The aim of the present study was to characterize these D2 receptors on freshly isolated human trophoblastic cells. The binding of [3H]-spiperone to these cells showed a curvilinear Scatchard plot suggesting the presence of two classes of binding sites (Kd1=1, 26nM; Kd2 = 44, 3nM). Competition experiments showed the following inhibitory binding potencies: serotonin-2 (5-HT2) ≥ D2 >>> α-adrenergic, β-adrenergic, D1-dopamine, thus suggesting the presence of 5-HT2 binding sites. We have examined this possibility by blocking [3H]-splperone binding to 5-HT2 receptors in the presence of 50nM ketanserin, a selective antagonist of 5-HT2 sites. Under this condition, the linear Scatchard plot obtained suggested a single population of homogenous binding sites for [3H]-spiperone with a Kd of 0,55nM. To further characterize placental D2 receptors we conducted binding experiments with [3H]-raclopride, an more selective D2 antagonist. The linear Scatchard plot obtained with this ligand suggested one class of binding sites for[3H]-raclopride (Kd = 6nM) with the following inhibitory potencies: D2 >>> β-adrenergic » 5-HT2, D1, α-adrenergic. These results suggest an important paracrine function for DA in human placenta and show for the first time that [3H]-spiperone binds putative 5-HT2 receptors in human placenta." @default.
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• W2030896727 date "1994-01-01" @default.
• W2030896727 modified "2023-10-18" @default.
• W2030896727 title "Labelling of D₂-Dopaminergic and 5-HT₂-Serotonergic Binding Sites in Human Trophoblatic Cells Using [³H]-Spiperone" @default.
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• W2030896727 doi "https://doi.org/10.3109/10799899409066993" @default.
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