FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2030897839> ?p ?o ?g. }

• W2030897839 endingPage "1291" @default.
• W2030897839 startingPage "1279" @default.
• W2030897839 abstract "The tumor suppressor p53 is a critical regulator of apoptosis and cell cycle arrest/pro-survival. Upon DNA damage, p53 evokes both cell cycle arrest/pro-survival and apoptosis transcriptional programs. The ultimate cellular outcome depends on the balance of these two programs. However, the p53 downstream targets that mediate this cell fate decision remain to be identified. Using an integrative genomic approach, we identify Rap2b as a conserved p53-activated gene that counters p53-mediated apoptosis after DNA damage. Upon DNA damage, p53 directly binds to the promoter of Rap2b and activates its transcription. The reduction of Rap2b levels by small interference RNA sensitizes cells to DNA damage-induced apoptosis in a p53-dependent manner. Consistent with its pro-survival function, analysis of cancer genomic data reveals that Rap2b is overexpressed in many types of tumors. Anchorage-independent growth assays show that Rap2b has only weak transformation activity, suggesting that it is not an oncogene by itself. Together, our results identify Rap2b as a new player in the pro-survival program conducted by p53 and raise the possibility that targeting Rap2b could sensitize tumor cells to apoptosis in response to DNA damage." @default.
• W2030897839 created "2016-06-24" @default.
• W2030897839 creator A5001877853 @default.
• W2030897839 creator A5006080567 @default.
• W2030897839 creator A5010311406 @default.
• W2030897839 creator A5014963018 @default.
• W2030897839 creator A5029075394 @default.
• W2030897839 creator A5029279173 @default.
• W2030897839 creator A5044954997 @default.
• W2030897839 creator A5049190917 @default.
• W2030897839 creator A5077050764 @default.
• W2030897839 date "2013-04-15" @default.
• W2030897839 modified "2023-10-16" @default.
• W2030897839 title "Rap2b, a novel p53 target, regulates p53-mediated pro-survival function" @default.
• W2030897839 cites W1591281137 @default.
• W2030897839 cites W1868102126 @default.
• W2030897839 cites W1964719993 @default.
• W2030897839 cites W1964742508 @default.
• W2030897839 cites W1965531793 @default.
• W2030897839 cites W1966791160 @default.
• W2030897839 cites W1973788312 @default.
• W2030897839 cites W1978503888 @default.
• W2030897839 cites W1979245454 @default.
• W2030897839 cites W1982545065 @default.
• W2030897839 cites W1982861164 @default.
• W2030897839 cites W1994015824 @default.
• W2030897839 cites W1994838747 @default.
• W2030897839 cites W1995673543 @default.
• W2030897839 cites W2004042953 @default.
• W2030897839 cites W2007367353 @default.
• W2030897839 cites W2007625686 @default.
• W2030897839 cites W2007978249 @default.
• W2030897839 cites W2008715871 @default.
• W2030897839 cites W2009845042 @default.
• W2030897839 cites W2009931781 @default.
• W2030897839 cites W2014385820 @default.
• W2030897839 cites W2017188188 @default.
• W2030897839 cites W2024957578 @default.
• W2030897839 cites W2025722611 @default.
• W2030897839 cites W2028468783 @default.
• W2030897839 cites W2030071293 @default.
• W2030897839 cites W2034059961 @default.
• W2030897839 cites W2038324148 @default.
• W2030897839 cites W2038566673 @default.
• W2030897839 cites W2045086385 @default.
• W2030897839 cites W2050502393 @default.
• W2030897839 cites W2052887017 @default.
• W2030897839 cites W2054264611 @default.
• W2030897839 cites W2060736868 @default.
• W2030897839 cites W2063047906 @default.
• W2030897839 cites W2063669247 @default.
• W2030897839 cites W2068549027 @default.
• W2030897839 cites W2071639789 @default.
• W2030897839 cites W2074222004 @default.
• W2030897839 cites W2079852484 @default.
• W2030897839 cites W2084733813 @default.
• W2030897839 cites W2085252210 @default.
• W2030897839 cites W2091151265 @default.
• W2030897839 cites W2093469127 @default.
• W2030897839 cites W2097933346 @default.
• W2030897839 cites W2122637308 @default.
• W2030897839 cites W2127429864 @default.
• W2030897839 cites W2133373613 @default.
• W2030897839 cites W2133959309 @default.
• W2030897839 cites W2137840425 @default.
• W2030897839 cites W2143206501 @default.
• W2030897839 cites W2170175460 @default.
• W2030897839 cites W2171407623 @default.
• W2030897839 doi "https://doi.org/10.4161/cc.24364" @default.
• W2030897839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3674092" @default.
• W2030897839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23535297" @default.
• W2030897839 hasPublicationYear "2013" @default.
• W2030897839 type Work @default.
• W2030897839 sameAs 2030897839 @default.
• W2030897839 citedByCount "42" @default.
• W2030897839 countsByYear W20308978392013 @default.
• W2030897839 countsByYear W20308978392014 @default.
• W2030897839 countsByYear W20308978392015 @default.
• W2030897839 countsByYear W20308978392016 @default.
• W2030897839 countsByYear W20308978392017 @default.
• W2030897839 countsByYear W20308978392018 @default.
• W2030897839 countsByYear W20308978392019 @default.
• W2030897839 countsByYear W20308978392020 @default.
• W2030897839 countsByYear W20308978392021 @default.
• W2030897839 crossrefType "journal-article" @default.
• W2030897839 hasAuthorship W2030897839A5001877853 @default.
• W2030897839 hasAuthorship W2030897839A5006080567 @default.
• W2030897839 hasAuthorship W2030897839A5010311406 @default.
• W2030897839 hasAuthorship W2030897839A5014963018 @default.
• W2030897839 hasAuthorship W2030897839A5029075394 @default.
• W2030897839 hasAuthorship W2030897839A5029279173 @default.
• W2030897839 hasAuthorship W2030897839A5044954997 @default.
• W2030897839 hasAuthorship W2030897839A5049190917 @default.
• W2030897839 hasAuthorship W2030897839A5077050764 @default.
• W2030897839 hasBestOaLocation W20308978391 @default.
• W2030897839 hasConcept C105696609 @default.
• W2030897839 hasConcept C143425029 @default.
• W2030897839 hasConcept C153911025 @default.

• next